Numerical prediction of the effect of aortic Left Ventricular Assist Device outflow-graft anastomosis location

• Autorzy: Mazzitelli R. , Boyle F. , Murphy E. , Renzulli A. , Fragomeni G.

Identyfikatory

DOI

10.1016/j.bbe.2016.01.005

• Języki publikacji: EN

Abstrakty

EN

A Left Ventricular Assist Device (LVAD) is used to provide haemodynamic support to patients with critical cardiac failure. As LVADs generate continuous flow to better understand the haemodynamic effects of these devices under different working conditions, and particularly in relation to possible outflow-graft anastomosis location, we performed 3D one-way-coupled fluid–structure-interaction (FSI) for three different LVAD working conditions and with the anastomosis location in the ascending aorta and in the descending aorta. The anatomical model used in this study is a patient-specific geometry reconstructed from computed tomography images and the mechanical support considered is similar to the Jarvik 2000®Heart LVAD. Endothelial cells can be influenced by wall stress generated from the blood flow in the artery, so they can produce vascular complications. For this reason, the second aim of this study is to evaluate and analyse, using different mechanical indicators, the wall shear distribution upon the luminal surface of the aorta generated by an LVAD. These numerical investigations demonstrate the utility of one-way-coupled FSI models to compare the haemodynamic conditions for the two LVAD outflow-grafts anastomosis locations and how both affect the aorta and its wall stress. Furthermore, the mechanical indicators allow the identification of wall regions at greater risk of atherosclerosis. The results of this study indicate that an LVAD outflow-graft anastomosis location in the ascending aorta is the optimal configuration.

Słowa kluczowe

EN

left ventricular assist device; cardiovascular simulation; fluid structure interaction; wall shear stress; human aorta; 3D reconstruction

PL

urządzenie wspomagania lewej komory; symulacja krążeniowa; naprężenie styczne ścian; aorta ludzka; rekonstrukcja 3D

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2016
• Tom: Vol. 36, no. 2
• Strony: 327--343
• Opis fizyczny: Bibliogr. 53 poz., rys., tab., wykr.

Twórcy

autor

Mazzitelli R.

• School of Computer and Biomedical Engineering, ‘‘Magna Græcia’’ University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy; School of Mechanical & Design Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland

autor

Boyle F.

• School of Mechanical & Design Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland

autor

Murphy E.

• School of Mechanical & Design Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland

autor

Renzulli A.

• Cardiac Surgery Unit, ‘‘Magna Græcia’’ University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy

autor

Fragomeni G.

• School of Computer and Biomedical Engineering, ‘‘Magna Græcia’’ University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.