Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module

• Autorzy: Kilian K. , Pękal A. , Juszczyk J.

Identyfikatory

DOI

10.1515/nuka-2016-0007

• Konferencja: Proceedings of the Warsaw Medical Physics Meeting 2014 (2014 ; 15-17 May ; Warsaw, Poland)
• Języki publikacji: EN

Abstrakty

EN

A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 L solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The fi nal product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.

Słowa kluczowe

EN

11C-methionine; 11C-radiopharmaceuticals; gas phase iodination

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2016
• Tom: Vol. 61, No. 1
• Strony: 29--33
• Opis fizyczny: Bibliogr. 20 poz., rys.

Twórcy

autor

Kilian K.

• Heavy Ion Laboratory, University of Warsaw, 5a Pasteura Str., 02-093 Warsaw, Poland, Tel.: [phone]

autor

Pękal A.

• Heavy Ion Laboratory, University of Warsaw, 5a Pasteura Str., 02-093 Warsaw, Poland, Tel.: [phone]

autor

Juszczyk J.

• Faculty of Physics, University of Warsaw, 69 Hoża Str., 02-093 Warsaw, Poland

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.