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LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale : pharmacokinetic study after oral administration

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Although glimepiride (GLM) is the first-line treatment of Type II diabetes, low extraction recovery is still a significant limitation in previous plasma analysis methods. An optimized solid-phase extraction method of GLM in human plasma with excellent extraction recovery, 100 ± 0.06%, was achieved using liquid chromatography-electrospray ionization tandem mass spectrometry and Gliclazide (GLZ) as an internal standard. GLM was extracted from 100 µL plasma sample using Sep-Pak® vac 1cc (100 mg) C18 column and methylene chloride: methanol (2: 1, v/v) as eluant. Both GLM and GLZ were monitored by a triple quad mass spectrometer applying positive multiple reaction monitoring mode (+MRM). The protonated precursor ions and product ions of GLM and GLZ were m/z 491(352), and m/z 324 (127), respectively. The detection and measurement of low levels of GLM in human plasma reached to picogram range (limit of detection (LOD) = 60 pg/mL, limit of quantification (LOQ) = 200 pg/mL). The method was validated in terms of selectivity, linearity, recovery, accuracy, and precision. The method was successfully applied to the pharmacokinetic study of GLM following oral administration of 1 mg GLM tablets to 12 healthy volunteers.
Rocznik
Strony
12--17
Opis fizyczny
Bibliogr. 15 poz., rys., tab
Twórcy
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
  • Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
autor
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
  • Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Bibliografia
  • 1. McCall, A.L. Expert Opin. Pharmacother. 2001, 2, 699–713.
  • 2. Rosenstock, J. ; Samols, E. ; Muchmore, D.B. ; Schneider, J. Diabetes Care 1996, 19, 1194–1199.
  • 3. Langtry, H.D. ; Balfour, J.A. Drugs 1998, 55, 563–584.
  • 4. Moffat, A.C. ; Osselton, M.D. ; Widdop, B. Clarke's analysis of drugs and poisons, Pharmaceutical Press: London, 2011.
  • 5. Ratheiser, K. ; Korn, A. ; Waldhausl, W. ; Komjati, M. ; Vierhapper, H. ; Badian, M. ; Malerczyk, V. Arzneim. Forsch. 1993, 43, 856–858.
  • 6. El-Enany, N. M. ; Abdelal, A. A. ; Belal, F. F. ; Itoh, Y. I. ; Nakamura, M. N. Chem. Cent. J. 2012, 6, 9.
  • 7. Lakshmi, K. S. ; Rajesh, T. ISRN Pharm. 2011, 2011, 521353.
  • 8. Musmade, P. B. ; Talole, K. B. ; Deshpande, P. B. ; Karthik, A. ; Pathak, S. M. ; Pandey, S. ; Udupa, N. Arzneim. Forsch. 2011, 61, 23–31.
  • 9. Tripathi, A. S. ; Dewani, A. P. ; Shelke, P. G. ; Bakal, R. L. ; Chandewar, A. V. ; Mazumder, P. M. Drug Res. (Stuttg) 2013, 63, 510–514.
  • 10. Kundlik, M. L. ; Zaware, B. H. ; Kuchekar, S. R. J. Chromatogr. Sci. 2012, 50, 64–70.
  • 11. Surendran, S. ; Paul, D. ; Sushmita, R. ; Krishna, L. ; Tiwari, N. K. ; Giri, S. ; Satheeshkumar, N. J. Chromatogr. B 2017, 1046, 218–225.
  • 12. Strugaru, A.-M. ; Kazakova, J. ; Butnaru, E. ; Caba, I.-C. ; Bello-López, M. Á. ; Fernández-Torres, R. J. Pharm. Biomed. Anal. 2019, 165, 276–283.
  • 13. Zhu, J. ; Li, Y. ; Xiang, Y. ; Zhou, L. ; Li, Y. J. Pharm. Biomed. Anal. 2020, 184, 113180.
  • 14. U. S. P. Convention , U. S. Pharmacopoeia National Formulary. United States Pharmacopeial, 2012.
  • 15. Malerczyk, V. ; Badian, M. ; Korn, A. ; Lehr, K. H. ; Waldhausl, W. Drug Metab. Drug Interact. 1994, 11, 341–357.
Uwagi
Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-614f4655-62db-4a3c-9975-e97c09e1565e
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