Czynniki wirulencji bakterii - białkowe fosfatazy tyrozynowe : jako cel terapeutyczny w odpowiedzi na rozwijającą się antybiotykooporność

• Autorzy: Kostrzewa Tomasz , Styszko Joanna , Przychodzeń Paulina , Kamm Anna , Górska-Ponikowska Magdalena , Kuban-Jankowska Alicja

Warianty tytułu

EN

Protein tyrosine phosphatases - factors of bacterial virulence : as a therapeutic target in response to increasing antibiotic resistance

• Języki publikacji: PL

Abstrakty

EN

Microbial virulence is the ability of pathogen to penetrate, replicate, multiplícate and, as a consequence, damage the cells of the infected organism. In recent years, rapid progress in bacterial genome sequencing has led to the discovery and characterization of many new virulence factors. One of the many mechanisms of bacterial virulence is the activity of bacterial kinases and phosphatases. These enzymes phosphorylate and dephosphorylate various amino acid residues in proteins, most commonly serine, tyrosine and threonine. Reversible phosphorylation and dephosphorylation can control the activity of target proteins, either directly, by inducing conformational changes in proteins, or indirectly, by regulating protein-protein interactions. Due to the increasing antibiotic resistance, new substances that could be used to treat diseases caused by resistant bacterial strains are sought. One of the possibilities seems to be the inhibition of bacterial tyrosine phosphatases. Phosphorylation of proteins containing tyrosine residues is a key post-translational modification that controls the numerous cellular functions in bacteria. So far, many tyrosine phosphatases have been found to be responsible for the virulence of various bacterial strains. Many bacterial species use protein tyrosine phosphatases activity in host-pathogen interaction, by affecting signalling pathways and subsequent induction of the infection process. Many studies are devoted to the search for tyrosine phosphatases inhibitors in the context of possible support of the current antibacterial treatment. This article presents a review of reports on bacterial virulence factors-protein tyrosine phosphatases as potential therapeutic targets.

Słowa kluczowe

PL

antybiotykooporność; czynniki wirulencji bakterii; białkowe fosfatazy tyrozynowe; inhibitory PTPs

EN

antibiotic resistance; virulence factors; protein tyrosine phosphatases; PTPs inhibitors

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2019
• Tom: [Z] 73, 11-12
• Strony: 679--699
• Opis fizyczny: Bibliogr. 50 poz., rys., tab.

Twórcy

autor

Kostrzewa Tomasz

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

autor

Styszko Joanna

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

autor

Przychodzeń Paulina

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

autor

Kamm Anna

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

autor

Górska-Ponikowska Magdalena

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

autor

Kuban-Jankowska Alicja

• Gdański Uniwersytet Medyczny, Wydział Lekarski, Katedra Chemii Medycznej ul. Dębinki 1, 80-211 Gdańsk

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).