Assessment of seasonal variation of the bioactive oleuropein in Olea europaea L. leaves cultivated in Saudi Arabia

• Autorzy: Alqarni Mohammed Hamed , Salkini Mohamad Ayman , Alam Prawez , Alanazi Mazen Talal , Abdel-Kader Maged Saad , El Sohafy Samah M.

Identyfikatory

DOI

10.1556/1326.2021.00905

• Języki publikacji: EN

Abstrakty

EN

Plants secondary metabolites undergoes qualitative and quantitative variation due to environment al and growth factors. It is a crucial factor to select the proper time for collection of medicinal plants to assure maximum content of active components reflected as maximum efficacy. Olive leaves (Oleaeuropaea L.) are known traditionally for their antidiabetic effect. The secoiridoid glycoside oleur-opein is the main active component of Olive leaves responsible for the biological activity. The current study was conducted to monitor the seasonal variation of oleuropein in Olives leaves collected from the same location. To achieve this goal a validated HPLC method following the ICH guidelines was established. Separation was conducted using RP18 column and a mobile chase consisted of ultrapure water containing 20% acetonitrile and 1% acetic acid. Detection was performed at 254 nm with 1 mL/min flow rate. The method was simple, linear, accurate, precise, specific and robust. The analyses revealed considerable variations in the level of oleuropein throughout the year. This variation cannot be explained by temperature variation during the year. Two points of high levels of oleuropein were detected prior to flowering stage and ripening of the fruits. The levels of growth regulators most likely is responsible for the increased production of oleuropein. It is recommended that leaves intended for medicinal use to be collected during the fruiting stage prior to fruit ripening.

Słowa kluczowe

EN

oleuropein; Olea europaea L.; HPLC; ICH guidelines; seasonal variation

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 3
• Strony: 297--303
• Opis fizyczny: Bibliogr. 33 poz., rys., wykr.

Twórcy

autor

Alqarni Mohammed Hamed

• Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O.Box 173, 11942, Al-Kharj, Saudi Arabia

autor

Salkini Mohamad Ayman

• Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O.Box 173, 11942, Al-Kharj, Saudi Arabia

autor

Alam Prawez

• Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O.Box 173, 11942, Al-Kharj, Saudi Arabia

autor

Alanazi Mazen Talal

• College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, 11942, Al-Kharj, Saudi Arabia

autor

Abdel-Kader Maged Saad

• Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O.Box 173, 11942, Al-Kharj, Saudi Arabia
• Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, 21215, Alexandria, Egypt

• https://orcid.org/0000-0002-5128-2656

autor

El Sohafy Samah M.

• Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, 21215, Alexandria, Egypt

Bibliografia

• 1. Yeh, G. Y.; Eisenberg, D. M.; Kaptchuk, T. J.; Phillips, R. S. Diabetes Care 2003, 26, 1277–94.
• 2. Komaki, E.; Yamaguchi, S.; Kinoshita, M.; Kakehi, K.; Ohta, Y.; Tsukada, Y. Food Sci. Technol. Res. 2003, 9, 35–9.
• 3. Wainstein, J.; Ganz, T.; Boaz, M.; Bar Dayan, Y.; Dolev, E.; Kerem, Z.; Madar, Z. J. Med. Food 2012, 15, 605–10.
• 4. Sarbishegi, M.; Gorgich, E. A. C.; Khajavi, O. Nephrourology Monthly 2017, e47127.
• 5. Candar, A.; Demirci, H.; Baran, A. K.; Akpınar, Y. Complement. Ther. Clin. Pract. 2018, 31, 1–6.
• 6. Soliman, G. A.; Saeedan, A. S.; Abdel-Rahman, R. F.; Ogaly, H. A.; Abd-Elsalam, R. M.; Abdel-Kader, M. S. Saudi Pharm. J. 2019, 27, 326–40.
• 7. Cumaoglu, A.; Rackova, L.; Stefek, M.; Kartal, M.; Maechler, P.; Karasu, C. Acta Biochim. Pol. 2011, 58, 45–50.
• 8. Cardoso, S. M.; Falcao, S. I.; Peres, A. M.; Domingues, M. R. Food Chem. 2011, 129, 291–6.
• 9. Ghanbari, R.; Anwar, F.; Alkharfy, K. M.; Gilani, A. H.; Saari, N. Int. J. Mol. Sci. 2012, 13, 3291–340.
• 10. Cvjetićanin, T.; Milijkovic, D.; Stojanovic, I.; Dekanski, D.; Stosic-Grujicic, S. Br. J. Nutr. 2010, 103, 1413–24.
• 11. Cicerale, S.; Lucas, L. J.; Keast, R. S. T. Curr. Opin. Biotechnol. 2012, 23, 129–35.
• 12. Achat, S.; Tomao, V.; Madani, K.; Chibane, M.; Elmaataoui, M.; Dangles, O.; Chemat, F. Ultrason. Sonochem. 2012, 19, 777–86.
• 13. Anter, J.; Fernández-Bedmar, Z.; Villatoro-Pulido, M.; Demyda-Peyras, S.; Moreno-Millán, M.; Alonso-Moraga, A.; Muñoz-Serrano, A.; Luque de Castro, M. D. Mutat. Res. 2011, 723, 165–70.
• 14. Fabiani, R. P.; Rosignoli, A.; De Bartolomeo, R.; Fuccelli, M.; Servili, G. F.; Montedoro, G.; Morozzi. J. Nutr. 2008, 138, 1411–6.
• 15. Al-Azzawie, H. F.; M-Alhamdani, S. S. Life Sci. 2006, 78, 1371–8.
• 16. Jemai, H.; Bouaziz, M.; Fki, I.; Feki-El, A.; Sayadi, S. Chem. Biol. Interact. 2008, 176, 88–98.
• 17. Kotyzová, D.; Hodková, A.; Eybl, V. Toxicol. Lett. 2011, 205(Suppl.), S222.
• 18. Domitrović, R.; Jakovac, H.; Marchesi, V. V.; Sain, I.; Romić, Z.; Rahelic, D. Pharmacol. Res. 2012, 65, 451–64.
• 19. Andreadou, I.; Sigala, F.; Iliodromitis, E. K.; Papaefthimiou, M.; Sigalas, C.; Aligiannis, N.; Savvari, P.; Gorgoulis, V.; Papalabros, E.; Kremastinos, D. T. J. Mol. Cell. Cardiol. 2007, 42, 549–58.
• 20. Andreadou, I.; Papaefthimiou, M.; Zira, A.; Constantino, M.; Sigala, F.; Skaltsounis, A. L.; Tsantili-Kakoulidou, A.; Iliodromitis, E. K.; Kremastinos, D. T.; Mikros, E. NMR in Biomed. 2009, 22, 585–92.
• 21. Hassen, I.; Casabianca, H.; Hosni, K. J. Funct. Foods 2015, 18, 926–40.
• 22. Flemmig, J.; Kuchta, K.; Arnhold, J.; Rauwald, H. W. Phytomedicine 2011, 18, 561–6.
• 23. Pitozzi, V.; Jacomelli, M.; Zaid, M.; Luceri, C.; Bigagli, E.; Lodovici, M.; Ghelardini, C.; Vivoli, E.; Norcini, M.; Esposto, M. S.; Servili, M.; Morozzi, G.; Baldi, E.; Bucherelli, C.; Dolara, P.; Giovanelli, L. Br. J. Nutri. 2010, 103, 1674–83.
• 24. Jacomelli, M.; Pitozzi, V.; Zaid, M.; Larrosa, M.; Tonini, G.; Martini, A.; Urbani, S.; Taticchi, A.; Servili, M.; Dolara, P.; Giovenelli, L. J. Nutr. Biochem. 2010, 21, 290–6.
• 25. Perugini, P.; Vettor, M.; Rona, C.; Troisi, L.; Villanova, L.; Genta, I.; Conti, B.; Pavanetto, F. Int. J. Cosmet. Sci. 2008, 30, 113–20.
• 26. Santiago-Mora, R.; Casado-Dıaz, A.; De Castro, M. D.; Quesada-Gómez, J. M. Osteoporos. Int. 2011, 22, 675–84.
• 27. Mehraein, F.; Sarbishegi, M. A. Wounds 2014, 26, 83–8.
• 28. Hamrouni, S. I.; Emna, M.; Thouraya, C.; Aidi, W. W; Elyes, K. M.; Brahim, M. Ind. Crops. Prod. 2009, 30, 395–402.
• 29. Firdous, R.; Gilani, A. H. Asian-Australasian J. Ani. Sci. 2001, 14, 935–42.
• 30. ICH, 2005. International Conference on Harmonization (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use, Harmonised Triplicate Guideline on Validation of Analytical Procedures: Text and Methodology Q2 (R1), Complementary Guideline on Methodology Incorporated in November 2005 by the ICH Steering Committee, IFPMA: Geneva.
• 31. https://en.climate-data.org/asia/saudi-arabia/ha-il-region/hail-34016/.
• 32. Huang, S. R.; Vishwakarma, K.; Lee-Chan, H. S.; Tsay, H. S. Bot. Stud. 2014, 55, 2–8.
• 33. Konno, K.; Hirayama, C.; Yasui, H.; Nakamura, M. Proc. Nat. Acad. Sci. 1999, 96, 9159–64.