Chromatographic methods and approaches for bioequivalence study, drug screening and enantioseparation of indapamide

• Autorzy: Sethi Sonika , Martens Jürgen , Bhushan Ravi

Identyfikatory

DOI

10.1556/1326.2023.01123

• Języki publikacji: EN

Abstrakty

EN

Indapamide (Indp) and certain other diuretics have been abused in sports, therefore, having sensitive methods for its detection and assay in biological fluids (whole blood, plasma, serum, and urine) is of significant importance. The racemic mixture of Indp is being used as an active pharmaceutical ingredient among other commonly prescribed diuretics. The regulatory authorities and pharmaceutical industries demand analytical methods for successful enantioseparation of such molecules. The paper presents a critical overview of the scientific issues of the application of contemporary techniques involving various chromatographic approaches (with liquid or supercritical fluid as mobile phases) and capillary electrophoresis and method development, for drug screening, assay, bioequivalence studies and enantioseparation of indapamide with their results. It also covers the historical developments that led to significant breakthroughs in research and concise evaluations of research in the area. Different types of chromatographic methods (HPLC, CEC, SFC etc) discussed herein provide an insight and a choice to select a method to (i) screen Indp for drug abuse, (ii) separate, isolate and quantify the enantiomers of Indp and (iii) investigate their pharmacokinetics as markedly different species and not as a total drug. The article evaluates the field’s status with a broad base and practical oriented approach so that the underlying principles are easily understood to help chemists and nonspecialists gain useful insights into the field outside their specialization and provide experts with summaries of key developments. To the best of authors’ knowledge there has been no attempt to review such methods for analysis of Indp and this is the first report of its kind.

Słowa kluczowe

EN

indapamide; bioequivalence study; drug screening; enantioseparation; high performance liquid chromatography; capillary electrophoresis; supercritical fluid chromatography

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2024
• Tom: Vol. 36, no. 2
• Strony: 67--85
• Opis fizyczny: Bibliogr. 78 poz., rys., wykr.

Twórcy

autor

Sethi Sonika

• Department of Chemistry, School of Engineering and Sciences, GD Goenka University, Gurgaon, 122103, Haryana, India

• https://orcid.org/0000-0002-9188-7465

autor

Martens Jürgen

• Institut für Chemie, Carl von Ossietzky Universität Oldenburg, D-26129, Oldenburg, Germany

autor

Bhushan Ravi

• Institut für Chemie, Carl von Ossietzky Universität Oldenburg, D-26129, Oldenburg, Germany
• Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India

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