Evaluation of design and insertion analysis of a conical shaped polymeric based microneedle for transdermal drug delivery applications

• Autorzy: Gera Aswani Kumar , Burra Rajesh Kumar

Identyfikatory

DOI

10.32933/ActaInnovations.46.4

• Języki publikacji: EN

Abstrakty

EN

Transportation of drug through parental routes are conventionally followed through hypodermic injection methods, where hypodermic injections are administered into the human skin for drug release. However, there are some issues observed when these hypodermic needles are being used, there are instances where the needle is being inserted leaves some needle fractures in the skin. To cater to the issue scientific researchers are voraciously working on designing and developing polymeric type of microneedle structures for various medical diagnostic applications for glucose monitoring, drug delivery, and other applications. This article presents the structural design of a conicalshaped polymeric microneedle and the insertion force while being pierced into the skin. Simulations at different insertion angles on microneedle are analyzed by arriving with total needle displacements in the process of insertion. The von mises stress is also analyzed with applied force at different insertion angles resulted in incremental change in stress exerted by the microneedle. The resultant stress is below the yield stress which makes the microneedle pierce into the skin without breakage.

Słowa kluczowe

EN

eco-friendly polymers; drug delivery; micro needle; transdermal drug delivery

PL

polimery ekologiczne; podawanie leków; mikro igła; transdermalne podawanie leków

• Wydawca: Centrum Badań i Innowacji Pro-Akademia ; Ukrainian Academy of Sciences - Research and Development Centre for Industrial Problems of Development
• Czasopismo: Acta Innovations
• Rocznik: 2023
• Tom: no. 46
• Strony: 54--65
• Opis fizyczny: Bibliogr. 26 poz.

Twórcy

autor

Gera Aswani Kumar

• Department of Electrical Electronics and Communication Engineering, School of Technology GITAM, Deemed to be University, Visakhapatnam, India

• https://orcid.org/0000-0002-8375-7580

autor

Burra Rajesh Kumar

• Department of Electrical Electronics and Communication Engineering, School of Technology GITAM, Deemed to be University, Visakhapatnam, India

• https://orcid.org/0000-0001-5081-7711

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).