One step 3D printing of surface functionalized composite scaffolds for tissue engineering applications

• Autorzy: Kotlarz M. , Jordan R. , Wegner E. , Dobrzyński P. , Neunzehn J. , Lederer A. , Wolf-Brandstetter C. , Pamula E. , Scharnweber D.

Identyfikatory

DOI

10.5277/ABB-01131-2018-02

• Języki publikacji: EN

Abstrakty

EN

A successful approach widely used in materials science to adapt approved materials to specific applications is to design their surface properties. A main challenge in this area is the development of processing routes enabling for a simple but efficient surface design of complex shaped geometries. Against this background, this work aimed at the implementation of self-assembly principles for surface functionalization of 3D-printed poly(lactic-co-glycolic acid) (PLGA)-based constructs with macro- and microporous geometries via precision extruding deposition. Methods: Three-component melts from PLGA, CaCO3 and amphiphilic polymers (poly(2-oxazoline) block copolymer) were printed and their bulk and surface properties were studied. Results: Melts with up to 30 mass % of CaCO3 could be successfully printed with homogeneously distributed mineral particles. PLGA degradation during the printing process was temperature and time dependent: the molecular weight reached 10 to 15% of the initial values after ca. 120 min of heat exposure. Filament surfaces from melts containing CaCO3 show an increasing microroughness along with increasing CaCO3 content. Surface roughness and amphiphilic polymer content improve scaffold wettability with both factors showing synergistic effects. The CaCO3 content of the melts affected the inner filament structure during in vitro degradation in PBS, resulting in a homogeneous mineral particle-associated microporosity for mineral contents of 20 mass % and above. Conclusions: These results provide novel insights into the behavior of three-component melts from PLGA, CaCO3 and amphiphilic polymers during precision extruding deposition and show for the first time that self-assembly processes can be used to tailor scaffolds surface properties under such processing conditions.

Słowa kluczowe

EN

3D printing; PLGA; calcium carbonate; amphiphilic poly(2-oxazoline); degradation; surface properties

PL

druk 3D; PLGA; węglan wapnia; właściwości powierzchniowe

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2018
• Tom: Vol. 20, no. 2
• Strony: 35--45
• Opis fizyczny: Bibliogr. 29 poz., rys., wykr.

Twórcy

autor

Kotlarz M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Krakow, Poland

autor

Jordan R.

• Technische Universität Dresden, Faculty of Chemistry and Food Chemistry, Chair of Macromolecular Chemistry, Dresden, Germany

autor

Wegner E.

• Technische Universität Dresden, Faculty of Chemistry and Food Chemistry, Chair of Macromolecular Chemistry, Dresden, Germany

autor

Dobrzyński P.

• Center of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland

autor

Neunzehn J.

• Technische Universität Dresden, Institut für Werkstoffwissenschaft, Max-Bergmann-Zentrum für Biomaterialien, Dresden, Germany

autor

Lederer A.

• Leibniz-Institut für Polymerforschung Dresden e.V., Institut für Makromolekulare Chemie, Polymer Separation Group, Dresden and Technische Universität Dresden, Dresden, Germany

autor

Wolf-Brandstetter C.

• Technische Universität Dresden, Institut für Werkstoffwissenschaft, Max-Bergmann-Zentrum für Biomaterialien, Dresden, Germany

autor

Pamula E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Krakow, Poland

autor

Scharnweber D.

• Technische Universität Dresden, Institut für Werkstoffwissenschaft, Max-Bergmann-Zentrum für Biomaterialien, Dresden, Germany

Bibliografia

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Uwagi

(GermanPolish project GoBone, No.01DS16010A) and AGH University of Science and Technology statutory founds (No. 11.11.160.182).

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).