Textile composite materials for small intestine replacement

• Autorzy: Deichmann T. , Michaelis I. , Junge K. , Tur M. , Michaeli W. , Gries T.
• Języki publikacji: EN

Abstrakty

EN

Down to the present day there are no sufficient techniques for a small intestine replacement, mostly because of the high standards for such implants. An indication for the need of novel operation techniques is the small patient survival rate of just 80 % for isolated small intestine transplantation and 62 % for combined liver-small intestine transplantation. The five year survival rates of the patients are merely 42 %. In order to overcome these limitations the authors are developing a partly resorbable textile-foam-composite for small intestine replacement The novel implant consists of a non resorbable textile PVDF mesh which is foamed with a micro porous, resorbable, and drug loaded polymer. The resorbable polymer serves on the one hand as initial sealing, therefore no intestine substance and bacteria can leak out into surrounding tissue, on the other hand it needs to be micro porous in order to ensure cell ingrowth. For the macro porous textile mesh warp knitting technology is used. The warp knitted tubular structure remains inside the body as a long term implant and provides mechanical support to ingrowing cells. In order to evaluate biomechanical properties of the warp knitted tubular PVDF meshes to compare them to the mechanical characteristics of small intestine tissue, tensile tests were conducted. Results of tensile tests on warp knitted structures with three different loop densities of 8, 12, and 16 loops per cm were compared to tensile tests on native small intestine tissue probes. The recorded curves of small intestine and warp knitted structures showed similar characteristics. The two characteristic Young Modules as well as the curve progression of the warp knitted structure with 12 loops per cm showed good accordance to the values of the native small intestine. Morphological analysis of the textile structures by digital image processing showed adequate pore size and porosity of the textile mesh.

Słowa kluczowe

EN

small intestine; implant; composite; warp knitting

PL

jelito cienkie; implant; kompozyt; dzianina osnowowa

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2009
• Tom: Vol. 9, no. 4
• Strony: 105--108
• Opis fizyczny: Bibliogr. 7 poz., il.

Twórcy

autor

Deichmann T.

• Institut für Textiltechnik, RWTH Aachen University, Aachen, Germany

autor

Michaelis I.

• Institute of Plastics Processing at RWTH Aachen University, Aachen, Germany

autor

Junge K.

• University Hospital Aachen, Department of Surgery, Aachen, Germany

autor

Tur M.

• Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany

autor

Michaeli W.

• Institute of Plastics Processing at RWTH Aachen University, Aachen, Germany

autor

Gries T.

• Institut für Textiltechnik, RWTH Aachen University, Aachen, Germany

Bibliografia

• 1. Winkler, M., Neue Entwicklung in der Immunsuppression nach Organtransplantation BGW-News/2004, URL: http://www.vod-ev.de/newsletter.htm.
• 2. Müller A, Pascher A, Platz K., Clinical Small Bowel Transplantation-Current Status and Initial Results, Transplantlinc 11 (2005).
• 3. Deltz E, Schroeder P, Gebhardt H., Successful clinical small bowel transplantation: report of a case, Clin Transplantation (1989).
• 4. Goulet O, Revullon Y, Jan D., Small bowel transplantation in children, TransplantProc 22: 2499-2500 (1990).
• 5. Grant D, Wall W, Mimault R., Successful small bowel-liver transplantation. Lancet, 335: 181-184 (1990).
• 6. Horbach T., Kurzdarmsyndrom, Der Chirurg, 12, 1169-1182 (2006).
• 7. Mühl T., Binnebösel M., Klinge U. Goedderz T., New objective measurement to characterize the porosity of textile implants, Journal of Biomedical Materials Research Part B: Applied Biomaterials 84, 176-183 (2007).