The effect of zinc oxide doping on mechanical and biological properties of 3D printed calcium sulfate based scaffolds

• Autorzy: Aldemir Dikici B. , Dikici S. , Karaman O. , Oflaz H.

Identyfikatory

DOI

10.1016/j.bbe.2017.08.007

• Języki publikacji: EN

Abstrakty

EN

Fabrication of defect-matching scaffolds is the most critical step in bone tissue engineering. Three-dimensional (3D) printing is a promising technique for custom design scaffold fabrication due to the high controllability and design independency. The objective of this study is to investigate the effect of zinc oxide (ZnO) doping on mechanical and biological characteristics of 3D printed (3DP) calcium sulfate hemihydrate (CSHH) scaffolds. Crystalline phases, wettability, compressive strength and Young's modulus, human bone marrow derived mesenchymal stem cells (hMSCs) attachment, proliferation and morphology were investigated. XRD results showed that CSHH powder transformed into gypsum after the printing process due to the water content of binder. Contact angle measurements indicated that ZnO doped CSHH scaffolds have hydrophilic character, which stimulates cell attachment. The mechanical and cell culture studies demonstrated that increasing the ZnO doping concentration both mechanical strength and cell proliferation on CSHH scaffolds were enhanced.

Słowa kluczowe

EN

three-dimensional printing; bone tissue engineering; calcium sulfate hemihydrate; zinc oxide; mechanical properties

PL

drukowanie przestrzenne; inżynieria tkanki kostnej; półwodzian siarczanu wapnia; tlenek cynku; właściwości mechaniczne

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2017
• Tom: Vol. 37, no. 4
• Strony: 733--741
• Opis fizyczny: Bibliogr. 39 poz., rys., wykr.

Twórcy

autor

Aldemir Dikici B.

• Biomechanics Division, Department of Biomedical Engineering, İzmir Katip Celebi University, İzmir, Turkey

autor

Dikici S.

• Biomechanics Division, Department of Biomedical Engineering, İzmir Katip Celebi University, İzmir, Turkey

autor

Karaman O.

• Division of Tissue Engineering, Faculty of Engineering and Architecture, Rm 148, İzmir Katip Celebi University, İzmir 35620, Turkey

autor

Oflaz H.

• Division of Biomechanics, Faculty of Engineering and Architecture, İzmir Katip Celebi University, İzmir 35620, Turkey

Bibliografia

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Uwagi

PL

Opracowanie w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).