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Termoczułe powierzchnie polimerowe i ich zastosowanie w inżynierii tkankowe
Języki publikacji
Abstrakty
This short review addresses the synthesis of thermoresponsive polymer surfaces and their application for cell tissue engineering. Four classes of synthetic thermoresponsive polymers are discussed: poly(N-isopropylacrylamide)s, poly[oligo(ethylene glycol)methacrylate]s, polyoxazolines and polyethers, most notably, polyglycidol. Synthetic routes leading to thermoresponsive layers on solid support are described. Relationships between structures of the layers and their interactions with cells are analyzed. Chemical (copolymerization or the inclusion of biologically active species) and physical (patterning or themorphology of the surfaces) modifications of macromolecular surfaces are described and their relations to the growth and detachment of cell sheets are reviewed. The application of cell sheets grown and detached from thermoresponsive surfaces to treat diseases is also presented.
Praca stanowi przegląd literatury dotyczącej syntezy termoczułych powierzchni polimerowych i ichzastosowania w inżynierii tkankowej. Omówionocztery klasy termoczułych polimerów: poli(N-izopropyloakryloamidy),poli(metakrylany glikoli oligoetylenowych), polioksazoliny i polietery, w tymprzede wszystkim poliglicydol. Opisano syntetyczne szlaki prowadzące do termoczułych warstw stabilnie i kowalencyjnie związanych ze stałym podłożem. Przeanalizowano zależności między strukturą warstw a ich oddziaływaniem z komórkami. Omówiono chemiczne(kopolimeryzacja, dołączenie do polimerubiologicznie aktywnego związku) i fizyczne (modelowanie, morfologia powierzchni) modyfikacje powierzchni polimerowych oraz ich związek ze wzrostem i odczepianiem komórek. Przedstawiono również zastosowanie wyhodowanychi odczepionych od termoczułych powierzchni komórek w postaci arkusza wleczeniu różnych chorób.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
327--338
Opis fizyczny
Bibliogr. 122 poz., tab.
Twórcy
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
autor
- Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
Bibliografia
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Uwagi
PL
Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-5e078d9c-a4d5-4c64-9dd9-66ae864d4cab