Influence of the position of the distal pressure measurement point on the Fractional Flow Reserve using in-silico simulations

• Autorzy: Agujetas Rafael , Ferrera Conrado , González-Fernández Reyes , Nogales-Asensio Juan M. , Fernández-Tena Ana

Identyfikatory

DOI

10.1016/j.bbe.2022.11.006

• Języki publikacji: EN

Abstrakty

EN

Coronary stenosis is mainly responsible for myocardial ischemia as the blood supply to a portion of the heart stops or is severely reduced. The Fractional Flow Reserve is the benchmark for the hemodynamic significance assessment of coronary stenoses. Its value is employed as a gatekeeper/planning tool for revascularization in clinical practice. Non-invasive alternatives have been successfully proposed to guide cardiologists. However, simulation values are not accurate enough in the 0.75-0.85 range, so invasive Fractional Flow Reserve should be used. Several authors argue about where distal pressure should be measured. Therefore, our aim is to use simulation to assess how this value changes and to detect the correct measurement region. First, we have adjusted the simulation method to the segmentations of two patients whose invasive Fractional Flow Reserve is known. We then extended our analysis to four patients and obtained the simulated value at multiple points distal to the stenosis. This is an advantage over invasive measurements, whose locations are restricted. The results are also essential for locating the best region for invasive distal pressure measurements. We propose a hybrid invasive and in-silico procedure that would avoid false results and prevent cardiologists from making erroneous clinical decisions.

Słowa kluczowe

EN

computational fluid dynamics; distal pressure; fractional flow reserve

PL

obliczeniowa dynamika płynów; ciśnienie dystalne; ułamkowa rezerwa przepływu

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2023
• Tom: Vol. 43, no. 1
• Strony: 69--81
• Opis fizyczny: Bibliogr. 39 poz., rys., tab., wykr.

Twórcy

autor

Agujetas Rafael

• Departamento de Ingeniería Mecánica, Energética y de los Materiales, Universidad de Extremadura, Badajoz, Spain
• Instituto de Computación Científica Avanzada de la Universidad de Extremadura (ICCAEx), Badajoz, Spain

autor

Ferrera Conrado

• Departamento de Ingeniería Mecánica, Energética y de los Materiales, Universidad de Extremadura, Badajoz, Spain
• Instituto de Computación Científica Avanzada de la Universidad de Extremadura (ICCAEx), Badajoz, Spain

autor

González-Fernández Reyes

• Departamento de Ciencias Biomédicas, Universidad de Extremadura, Badajoz, Spain
• Servicio de Cardiología del Hospital Universitario de Badajoz, Spain

autor

Nogales-Asensio Juan M.

• Departamento de Ciencias Biomédicas, Universidad de Extremadura, Badajoz, Spain
• Servicio de Cardiología del Hospital Universitario de Badajoz, Spain

autor

Fernández-Tena Ana

• Facultad de Enfermería, Universidad de Oviedo, Gijón, Spain
• Instituto Nacional de Silicosis, Oviedo, Spain
• Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain

Bibliografia

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)