Ultrasonic specific absorption rate in nanoparticle-mediated moderate hyperthermia

• Autorzy: Gambin Barbara , Kruglenko Eleonora

Identyfikatory

DOI

10.24425/bpasts.2021.137053

• Języki publikacji: EN

Abstrakty

EN

Magnetic nanoparticle’s different applications in nanomedicine, due to their unique physical properties and biocompatibility, were intensively investigated. Recently, Fe₃O₄ nanoparticles, are confirmed to be the best sonosensitizers to enhance the performance of HIFU (high intensity focused ultrasound). They are also used as thermo-sensitizers in magnetic hyperthermia. A new idea of dual, magneto-ultrasound, coupled hyperthermia allows the ultrasound intensity to be reduced from the high to a moderate level. Our goal is to evaluate the enhancement of thermal effects of focused ultrasound of moderate intensity due to the presence of nanoparticles. We combine experimental results with numerical analysis. Experiments are performed on tissue-mimicking materials made of the 5% agar gel and gel samples containing Fe₃O₄ nanoparticles with φ  = 100 nm with two fractions of 0.76 and 1.53% w/w. Thermocouples registered curves of temperature rising during heating by focused ultrasound transducer with acoustic powers of the range from 1 to 4 W. The theoretical model of ultrasound-thermal coupling is solved in COMSOL Multiphysics. We compared the changes between the specific absorption rates (SAR) coefficients determined from the experimental and numerical temperature rise curves depending on the nanoparticle fractions and applied acoustic powers.We confirmed that the significant role of nanoparticles in enhancing the thermal effect is qualitatively similarly estimated, based on experimental and numerical results. So that we demonstrated the usefulness of the FEM linear acoustic model in the planning of efficiency of nanoparticle-mediated moderate hyperthermia.

Słowa kluczowe

EN

ultrasonic hyperthermia; agar-based tissue mimicking phantom; magnetic nanoparticles; temperature; specific absorption rate; SAR

PL

hipertermia ultradźwiękowa; fantom imitujący tkankę na bazie agaru; nanocząstki magnetyczne; temperatura; SAR; współczynnik absorpcji właściwej

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2021
• Tom: Vol. 69, nr 3
• Strony: art. no. e137053
• Opis fizyczny: Bibliogr. 43 poz., rys., tab.

Twórcy

autor

Gambin Barbara

• Institute of Fundamental Technological Research, Polish Academy of Sciences, ul. Pawińskiego 5B, 02-106 Warsaw, Poland

• https://orcid.org/0000-0001-7212-0157

autor

Kruglenko Eleonora

• Institute of Fundamental Technological Research, Polish Academy of Sciences, ul. Pawińskiego 5B, 02-106 Warsaw, Poland

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).