Synthesis and antimicrobial activity of some new imidazolinone derivatives containing benzimidazole

• Autorzy: Mehta P. , Davadra P. , Shah N. , Joshi H.
• Języki publikacji: EN

Abstrakty

EN

In this study some new o-benzimidazol-2'-yl-benzamido-p'-benzamido-2-phenyl-4-substituted phenyl-5-oxo-Imidazolines 3a-3j were synthesized. To synthesized target molecules we used various substituted oxazolone derivatives, synthesized from substituted benzaldehyde with hippuric acid. Substituted oxazolones 2a-2j were reacted with carbohydrazide derivative of benzimidazole 1 in presence of pyridine as base to obtained substituted imidazolinone derivatives. All synthesized compounds were characterized by IR, 1H NMR, elemental analysis and further supported by mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity. All compounds showing good to moderate active against fungal strain as compare to standard drug.

Słowa kluczowe

EN

benzimidazole; imidazolinone; antimicrobial activity

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 10
• Strony: 74--80
• Opis fizyczny: Bibliogr. 25 poz., tab., wykr.

Twórcy

autor

Mehta P.

• Home Science Department, Dr. Subhash Mahila Arts, Commerce & Home Science College, Junagadh - 362 001, Gujarat, India

autor

Davadra P.

• Department of Chemistry, Saurashtra University, Rajkot - 360 005, Gujarat, India

autor

Shah N.

• Department of Chemistry, Saurashtra University, Rajkot - 360 005, Gujarat, India

autor

Joshi H.

• Department of Chemistry, Saurashtra University, Rajkot - 360 005, Gujarat, India

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Uwagi

PL

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