Properties of biodegradable polymer coatings with hydroxyapatite on a titanium alloy substrate

• Autorzy: Goldsztajn Karolina , Godzierz Marcin , Hercog Anna , Władowski Mariusz , Jaworska Joanna , Jelonek Katarzyna , Woźniak Anna , Kajzer Wojciech , Orłowska Ada , Szewczenko Janusz

Identyfikatory

DOI

10.37190/ABB-02351-2023-03

• Języki publikacji: EN

Abstrakty

EN

Titanium alloys are among the most widely used materials in medicine, especially in orthopedics. However, their use requires the application of an appropriate surface modification method to improve their properties. Such methods include anodic oxidation and the application of polymer coatings, which limit the release of alloying element ions. In addition, biodegradable polymer coatings can serve as a carrier for drugs and other substances. The paper presents the results of research on the physical properties of biodegradable polymer coatings containing na-noparticle hydroxyapatite on a titanium alloy substrate. Methods: A PLGA coating was used in the tests. The coatings on the substrate of the anodized Ti6Al7Nb alloy were applied by ultrasonic spray coating. The tests were carried out for coatings with various hydroxyapatite content (5, 10, 15, 20%) and thickness resulting from the number of layers applied (5, 10, 15 layers). The scope of the research included microscopic observations using scanning electron microscopy, topography tests with optical profilometry, structural studies using X-ray diffraction, as well as wettability and adhesion tests. Results: The results shows that with the use of ultrasonic spray coating system is possible to obtain the continuous coatings containing hydroxyapaptite. Conclusions: The properties of the coating can be controlled by changing the percentage of hydroxyapatite and the number of layers of which the coating is composed.

Słowa kluczowe

EN

titanium alloys; hydroxyapatite; adhesion of coatings; biodegradable polymer coatings; physical properties of coatings

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2024
• Tom: Vol. 26, no. 1
• Strony: 121--132
• Opis fizyczny: Bibliogr. 24 poz., rys., tab., wykr.

Twórcy

autor

Goldsztajn Karolina

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, Zabrze, Poland.

autor

Godzierz Marcin

• Polish Academy of Science, Centre of Polymer and Carbon Materials, Zabrze, Poland.

autor

Hercog Anna

• Polish Academy of Science, Centre of Polymer and Carbon Materials, Zabrze, Poland.

autor

Władowski Mariusz

• Optotom, Warszawa, Poland.

autor

Jaworska Joanna

• Polish Academy of Science, Centre of Polymer and Carbon Materials, Zabrze, Poland.

autor

Jelonek Katarzyna

• Polish Academy of Science, Centre of Polymer and Carbon Materials, Zabrze, Poland.

autor

Woźniak Anna

• Silesian University of Technology, Faculty of Mechanical Engineering, Department of Materials Engineering and Biomaterials, Gliwice, Poland.

autor

Kajzer Wojciech

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, Zabrze, Poland.

autor

Orłowska Ada

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, Zabrze, Poland.

autor

Szewczenko Janusz

• Silesian University of Technology, Faculty of Biomedical Engineering, Department of Biomaterials and Medical Device Engineering, Zabrze, Poland.

Bibliografia

• [1] ARONOV D., ROSEN R., RON E.Z., ROSENMAN G., Tunable hydroxyapatite wettability: Effect on adhesion of biological molecules, Process Biochemistry, 2006, Vol. 41, 2367–2372, DOI: https://doi.org/10.1016/j.procbio.2006.06.006
• [2] ASTI A., GASTALDI G., DORATI R., SAINO E., CONTI B., VISAI L., BENAZZO F., Stem Cells Grown in Osteogenic Medium on PLGA, PLGA/HA and Titanium Scaffolds for Surgical Applications, Bioinorganic Chemistry and Application, 2010, DOI: 10.1155/2010/831031. 132 K. GOLDSZTAJN et al.
• [3] BOSE S., KELLER S., ALSTROM T., BOISEN A., ALMDAL K., Process optimalization of Ultrasonic Spray Coating of Polymer Films, Langmuir, 2013, 29, 6911–6919, DOI: https://doi.org/10.1021/la4010246
• [4] GBD 2019 Fracture Collaborators: Global, regional, and national burden of bone fractures in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019, The Lancet, 2021, Vol. 2, 580–592.
• [5] GHERASIM O., GRUMEZESCU A.M., GRUMEZESCU V., ANDRONESCU E., NEGUT I., BIRCA A.C., GALATEANU B., HUDITA A., Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants, Polymers (Basel), 2021, Vol. 13, DOI: 10.3390/polym13244303.
• [6] GOREJOVÁ R., ORIŇAKOVÁ R., ORSÁGOVÁ KRÁLOVÁ Z.,SOPČÁK T., ŠIŠOLÁKOVÁ I., SCHNITZER M., KOHAN M., HUDÁK R., Electrochemical deposition of a hydroxyapatite layer onto the surface of porous additively manufactured Ti6Al4V scaffolds, Surface and Coatings Technology, 2023, Vol. 455, DOI: 10.1016/j.surfcoat.2022.129207.
• [7] JONES D., Pharmaceutical Applications of Polymers for Drug Delivery, Rapra Technology Limited, 2004.
• [8] KARAMBAKHSH A., AFSHAR A., MALEKINEJAD P., Corrosion Resistance and Color Properties of Anodized Ti-6Al-4V, Journal of Materials Engineering and Performance, 2010, Vol. 21, 121–127, DOI: https://doi.org/10.1007/s11665-010-9791-1
• [9] KIEL-JAMROZIK M., SZEWCZENKO J., BASIAGA M., NOWIŃSKA K., Technological capabilities of surface layers formation on implant made of Ti-6Al-4V ELI alloy, Acta Bioeng. Biomech., 2015, Vol. 17, 31–37, DOI: 10.5277/ABB-00065-2014-03.
• [10] KIM S.S., PARK M.S., JEON O., CHOI C.Y, KIM B.S., Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering, Biomaterials, 2006, 27, 1399–1409, DOI: 10.1016/j.biomaterials.2005.08.016.
• [11] KUMAR S., SINGH S., QUADIR S.S., JOSHI G., CHOUHAN M., PURI D., CHOUDHARY D., Polymeric (PLGA-based) nanocomposites for application in drug delivery: Current state of the art. and forthcoming perspectives, Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development, 2024, 277–324, DOI: https://doi.org/10.1016/B978-0-443-18915-9.00004-5
• [12] LI J., ZHANG T., LIAO Z., WEI Y., HANG R., HUANG D., Engineered functional doped hydroxyapatite coating on titanium implants for osseointegration, Journal of Materials Research and Technology, 2023, Vol. 27, 122–152, DOI: https://doi.org/10.1016/j.jmrt.2023.09.239
• [13] LIU X., CHU P.K., DING C., Surface modification of titanium, titanium alloys, and related materials for biomedical application, Mater. Sci. Eng. R, 2004, Vol. 47, 49–121, DOI: https://doi.org/10.1016/j.mser.2004.11.001
• [14] LUO R., NEU B., VENKATRAMAN S.S., Surface Functionalization of Nanoparticles to Control Cell Interactions and Drug Release, Small, 2012, Vol. 8, 2585–2594, DOI: 10.1002/smll.201200398.
• [15] MAKADIA H.K., SIEGEL S.J., Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier, Polymers, 2011, Vol. 3, 1377–1397, DOI: https://doi.org/10.3390/polym3031377
• [16] MARCINIAK J., Biomateriały, Publisher, Gliwice, Poland 2002.
• [17] PREZAS P., SOARES M., BORGES J., SILVA J., OLIVEIRA F., GRACA M., Bioactivity Enhancement of Plasma-Sprayed Hydroxyapatite Coatings through Non-Contact Corona Electrical Charging, Nanomaterials, 2023, Vol. 13, https://doi.org/10.3390/nano13061058.
• [18] SUN T., HUANG J., ZHANG W., ZHENG X., WANG H., LIU J., LENG H., YUAN W., SONG C., Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections, Bioactive Materials, 2023, Vol. 21, 44–56, DOI: https://doi.org/10.1016/j.bioactmat.2022.07.028.
• [19] SZEWCZENKO J., KAJZER W., GRYGIEL-PRADELOK M., JAWORSKA J., JELONEK K., NOWIŃSKA K., GAWLICZEK M., LIBERA M., MARCINKOWSKI A., KASPERCZYK J., Corrosion resistance of PLGA-coated biomaterials, Acta Bioeng. Biomech., 2017, Vol. 19, 173–179, DOI: 10.5277/ABB-00556-2016-04.
• [20] SZEWCZENKO J., KAJZER W., KAJZER A., BASIAGA M., KACZMAREK M., ANTONOWICZ M., NOWIŃSKA K., JAWORSKA J., JELONEK K., KASPERCZYK J., Biodegradable polimer coatings on Ti6Al7Nb alloy, Acta Bioeng. Biomech., 2019, Vol. 21, 83–92, DOI: 10.37190/ABB-01461-2019-01.
• [21] SZEWCZENKO J., Kształtowanie właściwości fizycznych i chemicznych warstwy wierzchniej implantów ze stopów tytanu dla traumatologii I ortopedii, Publisher, Gliwice 2014.
• [22] VARGA N., HORNOK V., JANOVÁK L., DÉKÁNY I., CSAPÓ E., The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles, Colloids and Surfaces B: Biointerfaces, 2019, Vol. 176, 212–218, https://doi.org/10.1016/j.colsurfb.2019.01.012.
• [23] WANG M., Surface Modification of Metallic Biomaterials for Orthopaedic Application, Materials Science Forum, 2009, 285–290, http://dx.doi.org/10.4028/www.scientific.net/MSF.618-619.285
• [24] ZIMA A., Wpływ dodatków modyfikujących na właściwości hydroksyapatytowych wielofunkcyjnych tworzyw implantacyjnych przeznaczonych na nośniki leków, PhD dissertation, AGH University, Kraków 2007.