Deep brain stimulation of the entorhinal cortex modulates CA1 theta-gamma oscillations in mouse models of preclinical Alzheimer’s disease

• Autorzy: Luo Yinpei , Sun Yuwei , Wen Huizhong , Wang Xing , Zheng Xiaolin , Ge Hongfei , Yin Yi , Wu Xiaoying , Li Weina , Hou Wensheng

Identyfikatory

DOI

10.1016/j.bbe.2022.12.010

• Języki publikacji: EN

Abstrakty

EN

Deep brain stimulation (DBS) is a neuromodulation method that modulates neuronal activity. A trend in the treatment of Alzheimer’s disease (AD) is targeting key points of neural circuits with DBS. Here, we explored the effects of DBS targeted to the entorhinal cortex (EC) on neurons in the hippocampal CA1 in a mouse model of preclinical AD. Specifically, we recorded field potential signals from CA1 in preclinical AD mice after DBS of the EC (1 h/day for 21 days of 100 lA, 90 ls, 10 Hz, biphasic square wave pulse) with in-vivo electrophysiology and evaluated corresponding changes in behavior with the open field task and Morris water maze (MWM) task. We also assessed changes in pathological markers and neurogenesis in the hippocampus with immunohistological staining. DBS of the EC increased theta and gamma power and modulated theta in the high gamma band (50-100 Hz) in preclinical AD mice. After DBS of the EC, these mice performed better in the MWM task and exhibited reduced deposition of beta-amyloid and neuronal changes including significant increases in proliferating neurons and immature neurons. This is the first study to target the EC with DBS and analyze resulting neural oscillations in the hippocampal CA1 in a model of preclinical AD. The findings support the use of DBS as a potential treatment for AD.

Słowa kluczowe

EN

Alzheimer’s disease; deep brain stimulation; entorhinal cortex; neural oscillations; neurogenesis

PL

choroba Alzheimera; stymulacja mózgu; oscylacja neuronowa; neurogeneza

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2023
• Tom: Vol. 43, no. 1
• Strony: 246--260
• Opis fizyczny: Bibliogr. 63 poz., rys., wykr.

Twórcy

autor

Luo Yinpei

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

autor

Sun Yuwei

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

autor

Wen Huizhong

• Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Army Medical University, Chongqing, China

autor

Wang Xing

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

autor

Zheng Xiaolin

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

autor

Ge Hongfei

• Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China

autor

Yin Yi

• Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China

autor

Wu Xiaoying

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

autor

Li Weina

• Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China

autor

Hou Wensheng

• Key Laboratory of Biorheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China
• Chongqing Medical Electronics Engineering Technology Research Center, Chongqing University, Chongqing, China

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)