Estimating the efficiency and purity for detecting annihilation and prompt photons for positronium imaging with J-PET using toy Monte Carlo simulation

• Autorzy: Das Manish , Mryka Wiktor , Beyene Ermias Y. , Parzych Szymon , Sharma Sushil , Stępień Ewa , Moskal Paweł

Identyfikatory

DOI

10.5604/01.3001.0054.1938

• Języki publikacji: EN

Abstrakty

EN

The positronium imaging technique represents a potential enhancement of the PET imaging method. Its core principle involves employing a β⁺ radiation source that emits additional gamma (γ) quanta referred to as prompt gamma. Our aim is to evaluate the capability to differentiate between annihilation and prompt gamma emissions, a vital aspect of positronium imaging. For this purpose, the selected isotopes should enable high efficiency and purity in detecting both prompt gamma and annihilation gamma. The assessment of the efficiency in identifying prompt and annihilation photons for various isotopes, which are potentially superior candidates for β⁺+ γ emitters, is conducted through toy Monte-Carlo simulation utilizing the cross-section formula for photon-electron scattering. In this article, we have performed calculations for efficiency and purity values across different isotopes under ideal conditions and examined how these values evolve as we incorporate the fractional energy resolution into the analysis. Ultimately, the primary goal is to determine the energy threshold that optimizes both efficiency and purity, striking a balance between accurately identifying and recording events of interest while minimizing contamination from undesired events.

Słowa kluczowe

EN

J-PET; positronium imaging; PET; medical imaging

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2023
• Tom: Vol. 19, no. 1
• Strony: 87--95
• Opis fizyczny: Bibliogr. 40 poz., rys., tab.

Twórcy

autor

Das Manish

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• 2Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0001-2901-1745

autor

Mryka Wiktor

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0006-7616-8290

autor

Beyene Ermias Y.

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0009-0002-8757-2169

autor

Parzych Szymon

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

autor

Sharma Sushil

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0001-8947-0110

autor

Stępień Ewa

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0003-3589-1715

autor

Moskal Paweł

• Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
• Centre for Theranostics, Jagiellonian University, Krakow, Poland

• https://orcid.org/0000-0002-4229-3548

Bibliografia

• 1. Alavi A, Werner TJ, Stępień EŁ, Moskal P. Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. Bio-Algorithms and Med-Systems 2021;17:203-12.
• 2. Vandenberghe S, Moskal P, Karp JS. State of the art in total body PET. EJNMMI Phys. 2020;7:1-33.
• 3. Moskal P, Positronium Imaging, 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, UK, 2019; pp. 1-3. https://ieeexplore.ieee.org/document/9059856.
• 4. Moskal P, Stępień E. Perspectives on translation of positronium imaging into clinics. Front. Phys. 2022;10: 969806.
• 5. Moskal P, Kisielewska D, Curceanu C, Czerwiński E, Dulski K, Gajos A, et al. Feasibility study of the positronium imaging with the J-PET tomograph. Phys. Med. Biol. 2019;64:055017.
• 6. Moskal P, Kisielewska D, Y. Shopa R, Bura Z, Chhokar J, Curceanu C, et al. Performance assessment of the 2 γpositronium imaging with the total-body pet scanners. EJNMMI Phys. 2020;7(1):44.
• 7. Moskal P, Dulski K, Chug N, Curceanu C, Czerwiński E, Dadgar M, et al. Positronium imaging with the novel Multiphoton Pet Scanner. Sci. Adv. 2021;7(42):eabh4394.
• 8. Karimi H, Moskal P, Żak A, Stępień E. 3D melanoma spheroid model for the development of positronium biomarkers. Sci Rep. 2023;13:7648.
• 9. Moskal P, Kubicz E, Grudzień G, Czerwiński E, Dulski K, Leszczyński B, et al. Developing a novel positronium biomarker for Cardiac Myxoma Imaging. EJNMMI Phys. 2023;10(1):22.
• 10. Moskal P, Stępień EŁ. Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators. PET Clinics 2020;15:439-52.
• 11. Sitarz M, Jean-Pierre Cussonneau, Matulewicz T, Haddad F. Radionuclide candidates for β+γ coincidence PET: An overview. Appl Radiat Isot 2020;155:108898-8.
• 12. Uenomachi M, Shimazoe K, Takahashi H. A double photon coincidence detection method for medical gamma-ray imaging. Bio-Algorithms and Med-Systems 2022;18:120-6.
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• 17. Kadrmas DJ, Hoffman JM. Methodology for Quantitative Rapid Multi-Tracer PET Tumor Characterizations. Theranostics 2013;3:757-73.
• 18. Moskal P, Niedźwiecki Sz, Bednarski T, Czerwiński E, Kapłon, Kubicz E, et al. Test of a single module of the J-PET scanner based on plastic scintillators. Nucl. Instrum. Methods Phys. Res. A: Accel. Spectrom. Detect. Assoc. Equip. 2014;764:317-21.
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• 20. Korcyl G, Hiesmayr BC, Jasinska B, Kacprzak K, Kajetanowicz M, Kisielewska D, et al. Evaluation of single-chip, real-time tomographic data processing on FPGA SOC devices. IEEE Trans Med Imaging. 2018;37(11):2526-35.
• 21. Moskal P, Jasińska B, Stępień EŁ, Bass SD. Positronium in medicine and biology. Nat. Rev. Phys 2019;1:527-9.
• 22. Bass SD, Mariazzi S, Moskal P, Stępień E. Colloquium: Positronium physics and biomedical applications. RMP 2023;95:021002.
• 23. Jasińska B, Zgardzińska B, Chołubek G, Pietrow M, Gorgol M, Wiktor K, et al. Human tissue investigations using pals technique - free radicals influence. Acta Phys. Pol. 2017;132(5):1556-9.
• 24. Dulski K, on behalf of the J-PET collaboration on. PALS Avalanche - A New PAL Spectra Analysis Software. Acta Phys. Pol. 2020;137:167-70.
• 25. Shibuya K, Saito H, Tashima H, Yamaya T. Using inverse Laplace transform in positronium lifetime imaging. Phys. Med. Biol. 2022;67:025009.
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• 28. Mryka W, Manish Das M, Beyene EY, Moskal P, Stępień E, On behalf of J-PET collaboration. Estimating influence of positron range in proton therapy beam monitoring with PET. Bio-Algorithms and Med-Systems. 2023;19:96-100.
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• 32. George KJH, Borjian S, Cross MC, Hicks JW, Schaffer P, Kovacs MS. Expanding the PET radioisotope universe utilizing solid targets on small medical cyclotrons. RSC Adv 2021;11:31098-123.
• 33. Matulewicz T, Radioactive nuclei for β + γ PET and theranostics: selected candidates. Bio-Algorithms and Med-Systems 2021;17:235-9.
• 34. Masełek R, Krzemien W, Klimaszewski K, Raczyński L, Kowalski P, Shopa R, et al. Towards 2+1 photon tomography: Energy-based selection of two 511 kev photons and a prompt photon with the J-pet scanner [Internet]. 2018 [posted 2018 March 2; cited 2023 Dec 19]. Available from: https://doi.org/10.48550/arXiv.1803.00996.
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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).