Impact of lower limb movements on iliac vein stenting in iliac vein compression syndrome patients: insights from computational modeling

• Autorzy: Lu Jian , Fan Zhenmin , Ye Xia , Deng Xiaoyan , Feng Hai , Liu Mingyuan

Identyfikatory

DOI

10.37190/ABB-02397-2024-04

• Języki publikacji: EN

Abstrakty

EN

Iliac vein stenting is the primary treatment for patients with iliac vein compression syndrome (IVCS). However, post-stent placement, patients often experience in-stent restenosis and thrombosis. Despite this, the role of lower limb movements in the functioning of stents and veins in IVCS patients remains unclear. This study aimed to address this knowledge gap by developing a computational model using medical imaging techniques to simulate IVCS after stent placement. Methods: This research used a patient-specific model to analyze the effects of lower extremity exercises on hemodynamics post-stent placement. We conducted a comprehensive analysis to evaluate the impact of specific lower limb movements, including hip flexion, ankle movement and pneumatic compression on the hemodynamic characteristics within the treated vein. The analysis assessed parameters such as wall shear stress (WSS), oscillatory shear index (OSI), and residence time (RRT). Results: The results demonstrated that hip flexion significantly disrupts blood flow dynamics at the iliac vein bifurcation after stenting. Bilateral and left hip flexion were associated with pronounced regions of low WSS and high OSI at the iliac-vena junction and the stent segment. Additionally, active ankle exercise (AAE) and intermittent pump compression (IPC) therapy were found to enhance the occurrence of low WSS regions along the venous wall, potentially reducing the risk of thrombosis poststent placement. Consequently, both active joint movements (hip and ankle) and passive movements have the potential to influence the local blood flow environment within the iliac vein after stenting. Conclusions: The exploration of the impact of lower limb movements on hemodynamics provides valuable insights for mitigating adverse effects associated with lower limb movements post iliac-stenting. Bilateral and left hip flexions negatively impacted blood flow, increasing thrombosis risk. However, active ankle exercise and intermittent pump compression therapies effectively improve the patency.

Słowa kluczowe

EN

iliac vein compression syndrome; hemodynamics; iliac vein stenting; lower limb movement

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2024
• Tom: Vol. 26, no. 1
• Strony: 23--35
• Opis fizyczny: Bibliogr. 41 poz., rys., tab., wykr.

Twórcy

autor

Lu Jian

• School of Mechanical Engineering, Jiangsu University of Technology, China.

autor

Fan Zhenmin

• School of Mechanical Engineering, Jiangsu University of Technology, China.

autor

Ye Xia

• School of Mechanical Engineering, Jiangsu University of Technology, China.

autor

Deng Xiaoyan

• Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, China.

autor

Feng Hai

• Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Center of Vascular Surger, China.

autor

Liu Mingyuan

• Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Center of Vascular Surger, China.

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