Mechanical properties of 3D printed pla scaffolds for bone regeneration

• Autorzy: Kundreckaitė Paula , Šešok Andžela , Stonkus Rimantas , Gaidulis Gediminas , Romańczuk-Ruszuk Eliza , Pauk Jolanta

Identyfikatory

DOI

10.2478/ama-2024-0072

• Języki publikacji: EN

Abstrakty

EN

The growing interest in biodegradable scaffolds for bone regeneration created a need to investigate new materials suitable for scaffold formation. Poly(lactic acid) (PLA) is a polymer commonly used in biomedical engineering, e.g. in tissue engineering as a biodegradable material. However, the mechanical behavior of PLA along its degradation time is still not explored well. For this reason, the mechanical properties of PLA scaffolds affected by incubation in physiological medium needs to be investigated to show the potential of PLA to be used as a material for biodegradable scaffold formation. The purpose of this research is to determine the mechanical properties of PLA scaffolds before and after incubation, and to apply constitutive material models for further behavior prediction. Two sets of PLA scaffolds were printed by the 3D printer “Prusa i3 MK3S” and sterilized by ultraviolet light and ethanol solution. The first set of specimens was incubated in DMEM (Dulbecco’s Modified Eagle Medium) for 60, 120, and 180 days maintaining 36.5 °C temperature. The mechanical properties of the scaffolds were determined after performing the compression test in the “Mecmesin MultiTest 2.5-i” testing stand with a force applied at two different speed modes. The obtained data was curve fitted with the hyperelastic material models for a model suitability study. The second set of specimens was incubated in PBS (Phosphate Buffered Saline) for 20 weeks and used in a polymer degradation study. The obtained results show that the mechanical properties of PLA scaffolds do not decrease during incubation in physiological medium for a predicted new bone tissue formation period, though hydrolysis starts at the very beginning and increases with time. PLA as a material seems to be suitable for the use in bone tissue engineering as it allows to form biocompatible and biodegradable scaffolds with high mechanical strength, required for effective tissue formation.

Słowa kluczowe

EN

scaffold; bone regeneration; poly(lactic acid); PLA; biodegradable polymers; mechanical properties; hyperelasticity

• Wydawca: Oficyna Wydawnicza Politechniki Białostockiej
• Czasopismo: Acta Mechanica et Automatica
• Rocznik: 2024
• Tom: Vol. 18, no. 4
• Strony: 682--689
• Opis fizyczny: Bibliogr. 32 poz., rys., tab., wykr.

Twórcy

autor

Kundreckaitė Paula

• Faculty of Mechanics, Department of Biomechanical Engineering, Vilnius Gediminas Technical University, Plytinės str. 25, Vilnius, Lithuania

• https://orcid.org/0009-0008-6483-0325

autor

Šešok Andžela

• Faculty of Mechanics, Department of Biomechanical Engineering, Vilnius Gediminas Technical University, Plytinės str. 25, Vilnius, Lithuania

• https://orcid.org/0000-0001-8194-1539

autor

Stonkus Rimantas

• Faculty of Mechanics, Department of Mechatronics, Robotics and Digital Manufacturing, Vilnius Gediminas Technical University, Plytinės str. 25, Vilnius, Lithuania

• https://orcid.org/0000-0002-1228-9433

autor

Gaidulis Gediminas

• Faculty of Mechanics, Department of Biomechanical Engineering, Vilnius Gediminas Technical University, Plytinės str. 25, Vilnius, Lithuania

• https://orcid.org/0000-0002-9317-8160

autor

Romańczuk-Ruszuk Eliza

• Institute of Biomedical Engineering, Bialystok University of Technology, Wiejska 45A, Bialystok, Poland

• https://orcid.org/0000-0001-5228-4920

autor

Pauk Jolanta

• Institute of Biomedical Engineering, Bialystok University of Technology, Wiejska 45A, Bialystok, Poland

• https://orcid.org/0000-0001-8607-7129

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