Poly(sebacic anhydride) microparticles loaded with curcumin for pulmonary purposes

• Autorzy: Kwiecień Konrad , Reczyńska-Kolman Katarzyna , Niewolik Daria , Jaszcz Katarzyna , Pamuła Elżbieta

Identyfikatory

DOI

10.34821/eng.biomat.162.2021.7-12

• Języki publikacji: EN

Abstrakty

EN

Microparticles (MPs) made of fast biodegrading biomaterials, loaded with drugs, are considered a superior treatment method for pulmonary infections. One of the promising biomaterials for obtaining such a drug delivery system (DDS) is poly(sebacic anhydride) (PSA) due to its favourable degradation kinetics and mechanism. In this paper, we present a study of manufacturing MPs from PSA loaded with curcumin (CU) for pulmonary purposes. MPs were manufactured by oil-in-water emulsification; their morphology and size distribution were evaluated using optical microscopy, while the encapsulation efficiency and drug loading were obtained by the fluorometric assay. The cytotoxicity of the MPs, both the empty ones and loaded with CU, was analysed by in vitro tests with BEAS-2B human lung epithelial cells. To this end, metabolic activity by AlamarBlue assay and fluorescent staining (DAPI/ eosin) of the cells were performed. The MPs produced were round, regular in shape with diameters in the range of 1-5 µm and of yellow colour originating from CU. The CU encapsulation efficiency ranged from 42% to 55% and decreased with a higher CU ratio. The drug loading ranged from 4% to 11% and increased at a higher CU ratio. Both empty and CU-loaded MPs did not show a cytotoxic effect at concentrations up to 10 µg/ml.

Słowa kluczowe

EN

poly(sebacic anhydride); curcumin; drug delivery system; pulmonary infections; polymeric microparticles

PL

lekarstwa; dystrybucja; infekcje pulmonologiczne

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2021
• Tom: Vol. 24, no. 162
• Strony: 7--12
• Opis fizyczny: Bibliogr. 24 poz., wykr., zdj.

Twórcy

autor

Kwiecień Konrad

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, A. Mickiewicz Av. 30, 30-059 Kraków, Poland

• https://orcid.org/0000-0002-9504-1205

autor

Reczyńska-Kolman Katarzyna

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, A. Mickiewicz Av. 30, 30-059 Kraków, Poland

• https://orcid.org/0000-0002-5266-9131

autor

Niewolik Daria

• Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody str. 9, 44-100 Gliwice, Poland

• https://orcid.org/0000-0003-2472-3943

autor

Jaszcz Katarzyna

• Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, M. Strzody str. 9, 44-100 Gliwice, Poland

• https://orcid.org/0000-0003-4883-8278

autor

Pamuła Elżbieta

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, A. Mickiewicz Av. 30, 30-059 Kraków, Poland

• https://orcid.org/0000-0002-0464-6189

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).