Biofunctional impact of textured coatings in the application of heart assist therapy

• Autorzy: Kurtyka Przemysław , Kopernik Magdalena , Kaczmarek Marcin , Surmiak Marcin , Major Łukasz , Kustosz Roman , Więcek Justyna , Kurtyka Klaudia , Bartkowiak Amanda , Major Roman

Identyfikatory

DOI

10.1007/s43452-022-00573-8

• Języki publikacji: EN

Abstrakty

EN

Due to a lack of organs, cardiac support systems are being implanted in patients with severe congestive heart failure. One of the solutions to overcome complications such as infow obstruction or pump thrombosis, which may occur in the case of ventricular assist devices, is to modify the surface of cannulas for the controlled blood clotting process. The results obtained up till now for developed surface coatings clearly show the influence of topographical and mechanical parameters of the coatings on cell viability and protein adsorption mechanism. The new coatings should enable the controlled growth of scar tissue, resulting in the limitation of thromboembolic events, and the reduction of cystic tissue growth into the fow lumen. The aim of this study is to evaluate the correlation between surface topography parameters on the susceptibility of cells to grow and adhere to the substrate as a solution with potential for use in MCS (mechanical circulatory support) devices. Research on surfaces used in MCS devices and on inflow cannulas has been carried out for many years, while the novelty of the present solution makes it a milestone within that type of application simultaneously allowing for appropriate selection of process parameters. Surface modifcation of titanium alloy Ti6Al7Nb was carried out using vacuum powder sintering of CP-Ti (commercially pure titanium) powder with two morphologies (regular spheres and irregular grains). The characterization of coatings obtained with the proposed method and the influence of measured topographic parameters (applying scanning electron microscopy, contact angle measurement and contact proflometry) on the cytotoxicity and susceptibility to protein adsorption were presented. Advanced albumin adsorption studies have fully confrmed the dependence of surface complexity on protein adsorption. The obtained results show a high potential of the produced coatings toward enabling permanent integration at the implant with the soft tissue.

Słowa kluczowe

EN

textured blood activation; vacuum powder sintering; heart assist system; protein adsorption

PL

teksturowana aktywacja krwi; próżniowe spiekanie proszków; system wspomagania serca; adsorpcja białek

• Wydawca: Springer ; Wrocław University of Science and Technology
• Czasopismo: Archives of Civil and Mechanical Engineering
• Rocznik: 2023
• Tom: Vol. 23, no. 1
• Strony: art. no. e31, 2023
• Opis fizyczny: Bibliogr. 40 poz., rys., tab., wykr.

Twórcy

autor

Kurtyka Przemysław

• Foundation of Cardiac Surgery Development, Institute of Heart Prostheses, 345A Wolności St., 41-800 Zabrze, Poland

autor

Kopernik Magdalena

• AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Cracow, Poland

autor

Kaczmarek Marcin

• Faculty of Biomedical Engineering, Silesian University of Technology, 40 Roosevelta St., 41-800 Zabrze, Poland

autor

Surmiak Marcin

• Department of Internal Medicine, Jagiellonian University Medical College, 8 Skawińska St., 31-066 Cracow, Poland

autor

Major Łukasz

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland

autor

Kustosz Roman

• Foundation of Cardiac Surgery Development, Institute of Heart Prostheses, 345A Wolności St., 41-800 Zabrze, Poland

autor

Więcek Justyna

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland

autor

Kurtyka Klaudia

• Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 Skłodowskiej-Curie St., 41-819 Zabrze, Poland

autor

Bartkowiak Amanda

• Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland

autor

Major Roman

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta St., 30-059 Cracow, Poland

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023)