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The catalyst-free polytransesterification for obtaining linear PGS optimized with use of 22 factorial design

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Poly(glycerol sebacate) (PGS) is a polyester that is particularly useful for tissue engineering appli- cations. Many researchers have focused on the application and characterization of materials made from PGS. Synthesis is often superficially described, and the prepolymer is not characterized before crosslinking. Considering the different functionality of each monomer (glycerine – 3, sebacic acid – 2), materials with a branched structure can be obtained before the crosslinking process. Branched struc- tures are not desirable for elastomers. In this work, method to obtain linear PGS resins is presented. Moreover, synthesis was optimized with the use of the Design of Experiments method for minimizing the degree of branching and maximizing the molecular weight. The process was described via mathe- matical models, which allows to the association of process parameters with product properties. In this work ca. 1kDa and less than 10% branched PGS resin was produced. This resin could be used to make very flexible elastomers because branching is minimized.
Rocznik
Strony
43--–52
Opis fizyczny
Bibliogr. 31 poz., rys., tab.
Twórcy
  • Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
autor
  • Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
  • Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
  • University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland
  • Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
  • Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland
Bibliografia
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  • 3. Gadomska-Gajadhur A.,Wrzecionek M., Matyszczak G., Pi˛etowski P.,Wi˛ecław M., Ruśkowski P., 2018. Optimization of poly(glycerol sebacate) synthesis for biomedical purposes with the design of experiments. Org. Process Res. Dev., 22, 1793–1800. DOI: 10.1021/acs.oprd.8b00306.
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  • 17. Li Y., Cook W.D., Moorhoff C., Huang W.-C., Chen Q.-Z., 2013. Synthesis, characterization and properties of biocompatible poly(glycerol sebacate) pre-polymer and gel. Polym. Int., 62, 534–47. DOI: 10.1002/pi.4419.
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  • 25. Ravichandran R., Venugopal J.R., Sundarrajan S., Mukherjee S., Sridhar R., Ramakrishna S., 2012. Minimally invasive injectable short nanofibers of poly(glycerol sebacate) for cardiac tissue engineering. Nanotechnology, 23, 385102. DOI: 10.1088/0957-4484/23/38/385102.
  • 26. Sant S.,Hwang C.M., Lee S.-H., Khademhosseini A., 2011. Hybrid PGS-PCL microfibrous scaffolds with improved mechanical and biological properties. J. Tissue Eng. Regener. Med., 5, 283–291. DOI: 10.1002/term.313.
  • 27. Saudi A., Rafienia M., Zargar Kharazi A., Salehi H., Zarrabi A., Karevan M., 2019. Design and fabrication of poly (glycerol sebacate)-based fibers for neural tissue engineering: synthesis, electrospinning, and characterization. Polym. Adv. Technol., 30, 1427–1440. DOI: 10.1002/pat.4575.
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  • 31. Xu B., Cook W.D., Zhu C., Chen Q., 2016. Aligned core/shell electrospinning of poly(glycerol sebacate)/poly(l-lactic acid) with tuneable structural and mechanical properties. Polym. Int., 65, 423–429. DOI: 10.1002/pi.5071.
Uwagi
Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-51ddced3-496d-4115-9bab-df91386a244e
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