Influence of process-material conditions on the structure and biological properties of electrospun polyvinylidene fluoride fibers

• Autorzy: Zaszczyńska A. , Sajkiewicz P. Ł. , Gradys A. , Tymkiewicz R. , Urbanek O. , Kołbuk D.

Identyfikatory

DOI

10.24425/bpasts.2020.133368

• Języki publikacji: EN

Abstrakty

EN

Polyvinylidene fluoride (PVDF) is one of the most important piezoelectric polymers. Piezoelectricity in PVDF appears in polar b and ɣ phases. Piezoelectric fibers obtained by means of electrospinning may be used in tissue engineering (TE) as a smart analogue of the natural extracellular matrix (ECM). We present results showing the effect of rotational speed of the collecting drum on morphology, phase content and in vitro biological properties of PVDF nonwovens. Morphology and phase composition were analyzed using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR), respectively. It was shown that increasing rotational speed of the collector leads to an increase in fiber orientation, reduction in fiber diameter and considerable increase of polar phase content, both b and g. In vitro cell culture experiments, carried out with the use of ultrasounds in order to generate electrical potential via piezoelectricity, indicate a positive effect of polar phases on fibroblasts. Our preliminary results demonstrate that piezoelectric PVDF scaffolds are promising materials for tissue engineering applications, particularly for neural tissue regeneration, where the electric potential is crucial.

Słowa kluczowe

EN

scaffolds; electrospinning; polyvinylidene fluoride; tissue engineering

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2020
• Tom: Vol. 68, nr 3
• Strony: 627--633
• Opis fizyczny: Bibliogr. 44 tab., rys., tab.

Twórcy

autor

Zaszczyńska A.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Laboratory of Polymers and Biomaterials, Pawińskiego 5B, 02-106 Warsaw, Poland

autor

Sajkiewicz P. Ł.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Laboratory of Polymers and Biomaterials, Pawińskiego 5B, 02-106 Warsaw, Poland

autor

Gradys A.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Laboratory of Polymers and Biomaterials, Pawińskiego 5B, 02-106 Warsaw, Poland

autor

Tymkiewicz R.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Department of Ultrasound, Pawińskiego 5B, 02-106 Warsaw, Poland

autor

Urbanek O.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Laboratory of Polymers and Biomaterials, Pawińskiego 5B, 02-106 Warsaw, Poland

autor

Kołbuk D.

• Institute of Fundamental Technological Research, Polish Academy of Sciences, Laboratory of Polymers and Biomaterials, Pawińskiego 5B, 02-106 Warsaw, Poland

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).