Sustained Release of Drug Facilitated Through Chemically Crosslinked Polyvinyl Alcohol-Gelatin (PVA-GE) Hydrogels. A sustainable biomedical approach

• Autorzy: Ali Shaukat , Ranjha Nazar Muhammad , Ahmad Bashir , Khan Ayaz Ali , Hassan Fakhr Ul , Aziz Tariq , Alharb Metab , Alshammari Abdulrahman , Alasmari Abdullah F. , Alharbi Mousa Esa

Identyfikatory

DOI

10.2478/pjct-2023-0017

• Języki publikacji: EN

Abstrakty

EN

The present study aimed to prepare hydrogel based on polyvinyl alcohol (PVA) and gelatin (Ge) and characterization of PVA/Ge hydrogel for their potential use as a sustained drug delivery system. Polyvinyl Alcohol (PVA) and-Gelatin (Ge) were cross-linked using glutaraldehyde (GA) as a crosslinking agent and hydrochloric acid (HCl) as a catalyst. Different feed polymer ratio and crosslinking agent concentration were used to prepare a series of PVA/Ge hydrogels. The obtained PVA/Ge hydrogels were investigated for dynamic and equilibrium swelling studies. The effect of polymers ratio, degree of crosslinking and pH of the medium on swelling of PVA/Ge hydrogels was investigated. Furthermore, the values of diffusion coeficient (D), volume fraction, polymer-solvent interaction parameter, molecular weight between crosslink and crosslink density were calculated. For swelling studies, 0.05M USP phosphate buffer solutions of different pH (1.2, 5.5, 6.5 and 7.5) were used. For the drug release study, ciprofloxacin HCl was loaded into selected samples as a model drug. The release of drug from these samples was performed for 12 hours in USP phosphate buffers of pH 1.2, 5.5 and 7.5. The release data from these samples were fitted into various kinetic models like zero order, first order, Higuchi and Peppas models to investigate the release mechanism. It was found that by varying the composition of PVA/Ge hydrogel and GA concentration, a significant difference was observed in drug release kinetics. FTIR spectroscopy and X-ray diffraction were used for the characterization of hydrogels. PVA/Ge hydrogel showed sustained release of the model drug at various pH values suggesting its potential use as a sustained drug delivery system.

Słowa kluczowe

EN

hydrogel; gelatin; drug release; ciprofloxacin HCl; polyvinyl alcohol

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2023
• Tom: Vol. 25, nr 2
• Strony: 56--65
• Opis fizyczny: Bibliogr. 46 poz., rys., tab., wz.

Twórcy

autor

Ali Shaukat

• Department of Pharmacy Bahauddin Zakariya University Multan, Punjab, Pakistan

autor

Ranjha Nazar Muhammad

• Department of Pharmacy Bahauddin Zakariya University Multan, Punjab, Pakistan

autor

Ahmad Bashir

• Department of Zoology, University of Malakand, Chakdara, 18800, Khyber Pakhtunkhwa, Pakistan

autor

Khan Ayaz Ali

• Department of Biotechnology, University of Malakand, Chakdara, 18800, Khyber Pakhtunkhwa, Pakistan

autor

Hassan Fakhr Ul

• Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Islamabad Pakistan

autor

Aziz Tariq

• Department of Agriculture, University of Ioannina, 47100 Arta, Greece

autor

Alharb Metab

• Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455,Riyadh 11451, Saudi Arabia

autor

Alshammari Abdulrahman

• Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455,Riyadh 11451, Saudi Arabia

autor

Alasmari Abdullah F.

• Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455,Riyadh 11451, Saudi Arabia

autor

Alharbi Mousa Esa

• Ministry of Health, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).