Quantitative analysis of Gamma Knife stereotactic radiosurgery for uveal melanoma

• Autorzy: Bisht Raj Kishor , Natanasabapathi Gopishankar , Kale Shashank Sharad

Identyfikatory

DOI

10.2478/pjmpe-2020-0012

• Języki publikacji: EN

Abstrakty

EN

The purpose of the study was to analyze single fraction Gamma Knife stereotactic radiosurgery (SRS) for uveal melanoma (UM). In the treatment of UMs, the dose distribution exhibited by an irregular eye surface has more calculation uncertainty. A tissue-equivalent bolus was placed on the left eye surface of a human head-shaped phantom. It was assumed that the treated eye is fixed using retrobulbar anesthesia and suture on extraocular muscles for phantom study. Leksell stereotactic frame was fixed around phantom’s head and the stereotactic computed tomography (CT) was performed. Two sets of scans were acquired (a) without bolus and (b) with a bolus of 1.0 cm thickness. These scans were transferred into a treatment planning system (TPS). The skull contouring was performed using stereotactic CT images. The target, visual pathways, and eye lens were delineated in stereotactic CT space created on TPS. A clinical relevant plan was designed on the CT study set “a” to deliver a radiation dose of 30Gy at tumor margin. The plan superimposed over CT study set “b” and compiled for convincing treatment strategy. The tumor coverage was 95% at 50% prescription isodose line. The conformity index, selectivity and the gradient index were 1.27, 0.80 and 3.28 respectively. The left optic nerve and eye lens received a maximum dose of 11.1 Gy and 11.0 Gy respectively. The treatment plan overlay showed similar planning indices and critical organ doses. The plan comparison showed: an irradiated volume received the radiation dose > 15 Gy varies < 1.0% whereas the volume received < 15 Gy were larger (> 1.0%) in the study set “b”. The distant lateral points from the target volume which describe the phantom’s eyelid showed a radiation dose of 3.2 Gy - 2.5 Gy. The doses to these points were misled and ignored in the CT study set “a”. The eye bolus provides better dosimetric information in the estimation of low dose areas which is commonly misled on TPS in SRS planning for UMs.

Słowa kluczowe

EN

Gamma Knife; phantom; bolus; stereotactic radiosurgery; uveal melanoma

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2020
• Tom: Vol. 26, Iss. 2
• Strony: 111--117
• Opis fizyczny: Bibliogr. 21 poz., rys., tab.

Twórcy

autor

Bisht Raj Kishor

• Department of Neurosurgery All India Institute of Medical Sciences New Delhi, India

autor

Natanasabapathi Gopishankar

• Dr B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences New Delhi, India

autor

Kale Shashank Sharad

• Department of Neurosurgery All India Institute of Medical Sciences New Delhi, India

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).