Mechanism of ligand binding – PDZ domain taken as example

• Autorzy: Dułak D. , Banach M. , Wiśniowski Z. , Konieczny L. , Roterman I.

Identyfikatory

DOI

10.1515/bams-2017-0022

• Języki publikacji: EN

Abstrakty

EN

Abstract: The mechanism of specific ligand binding by proteins is discussed using the PDZ domain complexing the pentapeptide. This process is critical for clustering the membrane ion channel. The traditional model based on the Beta-sheet extension by complexed pentapeptide is interpreted as a hydrophobic core extension supported by additional Beta-strand generated by complexed pentapeptide. The explanation is based on the fuzzy oil drop model applied to the crystal structure of PDZ-pentapeptide.

Słowa kluczowe

EN

hydrophobicity; ligand binding; PDZ domain

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2017
• Tom: Vol. 13, no. 4
• Strony: 175--178
• Opis fizyczny: Bibliogr. 15 poz., rys.

Twórcy

autor

Dułak D.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Lazarza 16, 31-530 Krakow, Poland

autor

Banach M.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Lazarza 16, 31-530 Krakow, Poland

autor

Wiśniowski Z.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Lazarza 16, 31-530 Krakow, Poland

autor

Konieczny L.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Lazarza 16, 31-530 Krakow, Poland

autor

Roterman I.

• Department of Bioinformatics and Telemedicine, Jagiellonian University – Medical College, Lazarza 16, 31-530 Krakow, Poland

Bibliografia

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