Synthesis and properties of bioresorbable and highly flexible 1,3-trimethylene carbonate/ε-caprolactone copolymers

• Autorzy: Pastusiak M. , Dobrzyński P. , Smola A. , Sobota M.
• Języki publikacji: EN

Abstrakty

EN

Ethyl etoxy zinc (II) has been prepared and emerged as very effective initiators for ring-opening polymerization of 1,3-trimethylene carbonate (TMC) and its copolymerization with ε-caprolactone (CL) to produce high molar mass polymers. The copolymerization of TMC and CL was performed in bulk at 120°C. The obtained copolymers were characterized by multiblock microstructure. The highest reactivity rate was demonstrated by trimethylene carbonate in comparison with ε-caprolactone monomer. The thermal and mechanical properties of the copolymers were strongly dependent on the monomer composition. Preliminary tests of monomers copolymerization using reactive extrusion yielded positive result.

Słowa kluczowe

EN

copolymerization; caprolactone; trimethylene carbonate; bioresorbable polymers

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 9--12
• Opis fizyczny: Bibliogr. 7 poz., rys., tab., wykr.

Twórcy

autor

Pastusiak M.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34 Sklodowska-Curie Street, 41-819 Zabrze, Poland

autor

Dobrzyński P.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34 Sklodowska-Curie Street, 41-819 Zabrze, Poland

autor

Smola A.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34 Sklodowska-Curie Street, 41-819 Zabrze, Poland

autor

Sobota M.

• Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34 Sklodowska-Curie Street, 41-819 Zabrze, Poland

Bibliografia

• [1] Lemmouchi Y., Schacht E., Kageruka P., De Deken R., Diarra B., Diall O., Geerts S.: Biodegradable polyesters for controlled release of trypanocidal drugs: In vitro and in vivo studies. Biomaterials 19 (1998) 1827-1837.
• [2] Pego A.P., Zhong Z., Dijkstra P.J., Grijpma D.W., Feijen J.: Influence of catalyst and polymerization conditions on the properties of 1,3-trimethylene carbonate and ε-caprolactone copolymers. Macromol. Chem. Phys. 204 (2003) 747-754.
• [3] Schappacher M., Fabre T., Mingotaud A.F, Soum A.: Study of a (trimethylenecarbonate-co-ε-caprolactone) polymer - Part 1: preparation of a new nerve guide through controlled random cpolymerization using rare earth catalysts Biomaterials 22 (2001) 2849-2855.
• [4] Sheng H., Zhou L., Zhang Y., et al.: Anionic lanthanide phenoxide complexes as novel single-component initiators for the polymerization of ε-caprolactone and trimethylene carbonate. J. Polym. Sci.: Part A: Polym. Chem. 45 (2007) 1210-1218.
• [5] Dobrzynski P.: Mechanism of ε-caprolactone polymerization and ε-caprolactone/trimethylene carbonate copolymerization carried out with Zr(Acac)4. Polymer 48 (2007) 2263-2279.
• [6] Kricheldorf H.R., Stricker A.: Polylactones, 47 A-B-A triblock copolyesters and random copolyesters of trimethylene carbonate and various lactones via macrocyclic polymerization. Macromol. Chem. Phys. 200 (1999) 1726-1733.
• [7] Kricheldorf H. R., Stricker A., Gomurashvili Z.: Polymers of carbonic acid, 30. Ring-expansion polymerization of trimethylene carbonate (TMC, 1,3-dioxanone-2) with dibutyltin succinate or adipate. Macromol. Chem. Phys. 202 (2001) 413-420.

Uwagi

EN

This research was investigated in the frame of project MEMSTEND UDA- POIG.01.03.01-00-123/08-00, co- financed by European Union.