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Języki publikacji
Abstrakty
A sensitive method was developed for the determination of free morphine and codeine in blood. This method is suitable for detection of the ingestion of illicit drugs. This test is applicable for monitoring therapeutic doses as well as stand up in the court of law. For the test we use with deuterium tagged morphine and codeine. We tag the blood specimens with deuterium prior to testing. The active ingredients (morphine and codeine) are extracted by solid phase extraction, and eventually derivatized with pentafluoro propionic anhydride (PFPA). The resulting compounds are stable and have good chromatographic characteristics. The Gas-chromatograph coupled Mass-spectrometer (GC/MS) system is used to determine the concentration of the resulting compounds using or/in the selective ion mode (SIM). The results of the target and qualifier ions were 414, 577, 361 in the case of morphine, and 282, 445 in the case of codeine. During our measurements, the graph was linear between 1 and 100 ng / mL. All the results of the qualifications were in line with the German Standards DIN 32645, which were checked with the B.E.N. program.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
351--365
Opis fizyczny
Bibliogr. 23 poz., rys., tab.
Twórcy
autor
- Hungarian Defence Forces Dr György Radó Military Medical Center Budapest Hungary
- H-1118 Budapest Rétköz utca 47/C, 2/2 Hungary
autor
- Hungarian Defence Forces Dr György Radó Military Medical Center Budapest Hungary
autor
- Hungarian Defence Forces Dr György Radó Military Medical Center Budapest Hungary
autor
- Scientific Institute Military Hospital-State Health Centre P.O. Box 1 H-1553 Budapest Hungary
autor
- Hungarian Defence Forces Dr György Radó Military Medical Center Budapest Hungary
autor
- Scientific Institute Military Hospital-State Health Centre P.O. Box 1 H-1553 Budapest Hungary
autor
- Hungarian Defence Forces Dr György Radó Military Medical Center Budapest Hungary
Bibliografia
- [1] Fed. Regist. 59, 29922 (1994)
- [2] J.H. Autry, III. Notice to all DHHS/NIDA Certified Laboratories, December 19, 1990. United States of America Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, Rockville, MD, 1990
- [3] M. Mátyus, Gy. Kocsis, and J. Fűrész, Honvédorvos, 57, 172–180 (2005)
- [4] M. Thevis, G. Opfermann, and W. Schaenzer, J. Anal. Toxicol., 27, 53–58 (2003)
- [5] R. Meatherall, J. Anal. Toxicol., 29, 301–308 (2005)
- [6] M. Herbold and G. Schmitt, B.E.N. Program, Institut für Rechts- und Verkehrsmedizin, Heidelberg, 1999
- [7] J.D. Ropero-Miller, M.K. Lambing, and R.E. Winecker, J. Anal. Toxicol., 26, 524–528 (2002)
- [8] K. Róna, K. Ary, and L. Vereczkey, Acta Pharm. Hung., 67, 51 (1997)
- [9] J. Trafkowski, B. Madea, and F. Musshoff, Ther. Drug Monit., 28, 552–558 (2006)
- [10] B.A. Rashid, G.W. Aherne, M.F. Katmeh, P. Kwasowski, and D. Stevenson, J. Chromatogr. A, 797, 245–250 (1998)
- [11] T. Hyötylainen, H. Keski-Hynnila, and M-L. Riekkola, J. Chromatogr. A, 771, 360–365 (1997)
- [12] O.H. Drummer, Clin. Biochem. Rev., 27, 147–159 (2006)
- [13] L. Tsanaclis and J.F. Wicks, Forensic Sci. Int., 170, 121–128 (2007)
- [14] T. Kramer and L.D. Paul, Anal. Bioanal. Chem., 388, 1415–1435 (2007)
- [15] R. Coles, M.M. Kushnir, G.J. Nelson, G.A. McMillin, and F.M. Urry, J. Anal. Toxicol., 31, 1–14 (2007)
- [16] L. Bachs, G. Hoiseth, S. Skurtveit, and J. Morland, Eur. J. Clin. Pharmacol., 62, 905–912 (2006)
- [17] Deutsches Institut für Normung 32645, Nachweis-, Erfassung- und Bestimmungsgrenze, Beuth Verlag, Berlin, 1994
- [18] M. Herbold and G. Schmitt, Toxichem. Krimtech., 65, 87–96 (1998)
- [19] G. Schmitt, M. Herbold, and F. Peters, Methodenvalidierung im forensisch-toxikologischen Labor. Arvecon GmbH, Heidelberg, 2003
- [20] M.J. Bogusz, K.D. Krüger, and R.D. Maier, J. Anal. Toxicol., 24, 77–87 (2000)
- [21] H.H. Maurer, Ther. Drug Monit., 24, 247–254 (2002)
- [22] M.R. Moeller and T Kraemer, Ther. Drug Monit, 24, 210–221 (2002)
- [23] F. Bressole, M. Bromet-Petit, and M. Audram, J. Chromatogr. B, 686, 3–10 (1996)
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-49761cb2-add0-4d55-bfd8-1f43742887cf