Determination of narciclasine in mouse blood by UPLC-MS/MS and its application to a pharmacokinetic study

• Autorzy: Ren Ke , Feng Tiantian , Shi Hai , Ma Jianshe , Jin Yongxi

Identyfikatory

DOI

10.1556/1326.2021.00865

• Języki publikacji: EN

Abstrakty

EN

Narciclasine is a 7-hydroxy derivative of lycorisidine. It was the first alkaloid isolated from the stem of narcissus (Amaryllidaceae) in 1967. Six mice were given narciclasine (5 mg/kg) by intravenous administration. A UPLC-MS/MS method was developed to determine narciclasine in mouse blood. Tectorigenin (internal standard, IS) and narciclasine were gradient eluted by mobile phase of methanol and 0.1% formic acid in a BEH C18 column. The multiple reaction monitoring (MRM) of m/z 308.1→248.1 for narciclasine and m/z 301.1→286.0 for IS with an electrospray ionization (ESI) source was used for quantitative determination. The calibration curve ranged from 1 to 6,000 ng/mL. The accuracy was from 92.5 to 107.3%, and the matrix effect was between 103.6 and 107.4%. The developed UPLC-MS/MS method was successfully applicated to a pharmacokinetic study of narciclasine in mice after intravenous administration (5 mg/kg).

Słowa kluczowe

EN

narciclasine; mice; UPLC-MS/MS; determination; bioavailability

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 2
• Strony: 115--119
• Opis fizyczny: Bibliogr. 26 poz., rys., tab.

Twórcy

autor

Ren Ke

• Department of Pharmacy, Ningbo YinZhou No.2 Hospital, Ningbo, China

autor

Feng Tiantian

• School of Basic Medicine, Wenzhou Medical University, Wenzhou, China

autor

Shi Hai

• Department of Pharmacy, Ningbo YinZhou No.2 Hospital, Ningbo, China

autor

Ma Jianshe

• School of Basic Medicine, Wenzhou Medical University, Wenzhou, China

• https://orcid.org/0000-0003-3432-3468

autor

Jin Yongxi

• Department of Rehabilitation, Wenzhou Municipal Hospital of Traditional Chinese Medicine, Wenzhou, China

• https://orcid.org/0000-0002-0191-4168

Bibliografia

• 1. Ding, Y.; Qu, D.; Zhang, K. M.; Cang, X. X.; Kou, Z. N.; Xiao, W.; Zhu, J. B. J. Asian Nat. Prod. Res. 2017, 19, 53–100.
• 2. Nair, J. J.; Bastida, J.; Codina, C.; Viladomat, F.; van Staden, J. Nat. Prod. Commun. 2013, 8, 1335–50.
• 3. N'Tamon, A. D.; Okpekon, A. T.; Bony, N. F.; Bernadat, G.; Gallard, J. F.; Kouame, T., Seon-Meniel, B., Leblanc, K., Rharrabti, S., Mouray, E., Grellier, P., Ake, M., Amin, N. C., Champy, P., Beniddir, M. A.; Le Pogam, P. Phytochemistry 2020, 179, 112485.
• 4. Gasca, C. A.; Moreira, N. C. S.; de Almeida, F. C.; Dutra-Gomes, J. V.; Castillo, W. O.; Fagg, C. W.; Magalhaes, P. O.; Fonseca-Bazzo, Y. M.; Sakamoto-Hojo, E., de Medeiros, Y. K., de Souza Borges, W.; Silveira, D. Food Chem. Toxicol. 2020, 111703.
• 5. Sibanyoni, M. N.; Chaudhary, S. K.; Chen, W.; Adhami, H. R.; Combrinck, S.; Maharaj, V.; Schuster, D.; Viljoen, A. Fitoterapia 2020, 146, 104650.
• 6. Koutova, D.; Maafi, N.; Havelek, R.; Opletal, L.; Blunden, G.; Rezacova, M.; Cahlikova, L. Molecules 2020, 25, 2337.
• 7. Trujillo-Chacon, L. M.; Alarcon-Enos, J. E.; Cespedes-Acuna, C. L.; Bustamante, L.; Baeza, M.; Lopez, M. G.; Fernandez-Mendivil, C.; Cabezas, F.; Pastene-Navarrete, E. R. Food Chem. Toxicol. 2019, 132, 110665.
• 8. Cole, E. R.; de Andrade, J. P.; Filho, J. F. A.; Schmitt, E. F. P.; Alves-Araujo, A.; Bastida, J.; Endringer, D. C.; de, S. B. W.; Lacerda, V. Anticancer Agents Med. Chem. 2019, 19, 707–17.
• 9. Nair, J. J.; Bastida, J.; van Staden, J. Nat. Prod. Commun. 2016, 11, 121–32.
• 10. Isbilen, O.; Rizaner, N.; Volkan, E. BMC Complement. Altern. Med. 2018, 18, 30.
• 11. Chen, M. X.; Huo, J. M.; Hu, J.; Xu, Z. P.; Zhang, X. Fitoterapia 2018, 130, 48–53.
• 12. Gopalakrishnan, R.; Matta, H.; Choi, S.; Chaudhary, P. M. Sci. Rep. 2020, 10, 5712.
• 13. Brautigam, J.; Bischoff, I.; Schurmann, C.; Buchmann, G.; Epah, J.; Fuchs, S.; Heiss, E.; Brandes, R. P.; Furst, R. J. Mol. Cel Cardiol. 2019, 135, 97–108.
• 14. Zhang, X.; Xiang, Q.; Zhao, X.; Ma, L.; Cui, Y. J. Clin. Pharm. Ther. 2019, 44, 163–73.
• 15. Millar, S. A.; Stone, N. L.; Yates, A. S.; O'Sullivan, S. E. Front. Pharmacol. 2018, 9, 1365.
• 16. Svagrova, I.; Stulik, K.; Pacakova, V.; Caliceti, P.; Veronese, F. M. J. Chromatogr. 1991, 563, 95–102.
• 17. Qiu, E. J.; Wang, H. Z.; Yu, Y.; Song, D. Z.; Cai, J. Z.; Ye, F. F. Latin Am. J. Pharm. 2020, 39, 1171–5.
• 18. Liu, Z. Z.; Liu, H. M.; Wu, Y. Z.; Xu, X. X.; Ma, J. S. Latin Am. J. Pharm. 2020, 39, 1116–21.
• 19. Chen, S. J.; Zhou, C. P.; Hu, Y. J.; Wang, H. Z.; Liu, F. L. Latin Am. J. Pharm. 2020, 39, 208–12.
• 20. Ye, W. J.; Lin, C. L.; Lin, G. Y.; Chen, R. J.; Sun, W.; Wang, S. H.; Wang, X. Q.; Zhou, Y. F. Curr. Pharm. Anal. 2019, 15, 604–11.
• 21. Song, H. C.; Huang, Y. W.; Zhu, D. Q.; Tong, S. H.; Zhang, M. L.; Wang, X. Q.; Bao, X. Curr. Pharm. Anal. 2019, 15, 194–9.
• 22. Li, T. R.; Ye, W. J.; Huang, B. G.; Lu, X. J.; Chen, X. X.; Lin, Y. J.; Wen, C. C.; Wang, X. Q. J. Pharm. Biomed. Anal. 2019, 168, 133–7.
• 23. Ren, K.; Jin, Y.; Wang, X. Q.; Wei, Z. Latin Am. J. Pharm. 2019, 38, 991–5.
• 24. Chen, L. G.; Yang, J. Y.; Chen, D. W.; Xiong, J. H.; Wang, X. Q.; Ying, X. Q.; Wei, Y. L.; Lin, Y. P.; Zhang, S. Z.; Wu, M. L. Latin Am. J. Pharm. 2019, 38, 855–9.
• 25. Chen, J. F.; Bao, X.; Lin, C. L.; Zhou, G. E. Latin Am. J. Pharm. 2019, 38, 985–90.
• 26. Chen, L. G.; Weng, Q. H.; Lin, Y. J.; Lu, X. J.; Zhong, Z. Q., Xiong, J. H.; Wang, X. Q. Curr. Pharm. Anal. 2020, 16, 705–11.

Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).