Mass and volume balances of nebulization processes for the determination of the expected dose of liquid medicines delivered by inhalation

• Autorzy: Sosnowski Tomasz R. , Janeczek Kamil , Grzywna Karolina , Emeryk Andrzej

Identyfikatory

DOI

10.24425/cpe.2021.138929

• Języki publikacji: EN

Abstrakty

EN

The works presents the application of mass/volume balances of liquid drug converted into the aerosol during atomization in medical nebulizers. The amount of liquid that can be delivered to the respiratory system during inhalation is reduced compared to the nominal dose not only because of drug losses both in the device (the residual volume, RV) and outside the nebulizer (in the mouthpiece, mask, or tubings), but also to the limitations of the patient (periodic flow with limited capacity). The paper should help to understand the complexity of aerosol therapy widely used in asthma, COPD and other pulmonary diseases.

Słowa kluczowe

EN

jet nebulizer; mesh nebulizer; residual volume of drug; inhaled dose; delivered dose; mass; balance

PL

nebulizator odrzutowy; nebulizator siatkowy; pozostała objętość leku; dawka wziewna; dostarczona dawka; masa; saldo

• Wydawca: Komitet Inżynierii Chemicznej i Procesowej Polskiej Akademii Nauk
• Czasopismo: Chemical and Process Engineering
• Rocznik: 2021
• Tom: Vol. 42, nr 3
• Strony: 253–--261
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Sosnowski Tomasz R.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, Waryńskiego 1, 00-645 Warsaw, Poland

autor

Janeczek Kamil

• Medical University of Lublin, Clinics of Lung Diseases and Pediatric Reumathology, Gębali 6, 20-093 Lublin, Poland

autor

Grzywna Karolina

• Silesian Medical University in Katowice, Student Scientific Club at the Chair and Division of Pathomorphology and Molecular Diagnostics, Medyków 18, 40-752 Katowice, Poland
• Silesian Medical University in Katowice, Faculty of Medical Sciences in Zabrze, Traugutta sq. 2, 41-800 Zabrze, Poland

autor

Emeryk Andrzej

• Medical University of Lublin, Clinics of Lung Diseases and Pediatric Reumathology, Gębali 6, 20-093 Lublin, Poland

Bibliografia

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