Effects of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-rich Fraction on ROS Generation in Proton Beam irradiated Human Colon Carcinoma Cells

• Autorzy: Sisin Noor Nabilah Talik , Akasaka Hiroaki , Sasaki Ryohei , Tominaga Takahiro , Miura Hayato , Nishi Masashi , Geso Moshi , Mat Nor Fazila Che , Razak Khairunisak Abdul , Rahman Wan Nordiana

Identyfikatory

DOI

10.2478/pjmpe-2022-0004

• Języki publikacji: EN

Abstrakty

EN

Introduction: Proton beam radiotherapy is an advanced cancer treatment technique, which would reduce the effects of radiation on the surrounding healthy cells. The usage of radiosensitizers in this technique might further elevate the radiation dose towards the cancer cells. Material and methods: The present study investigated the production of intracellular reactive oxygen species (ROS) due to the presence of individual radiosensitizers, such as bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) or baicalein-rich fraction (BRF) from Oroxylum indicum plant, as well as their combinations, such as BiONPs-Cis (BC), BiONPs-BRF (BB), or BiONPs-Cis-BRF (BCB), on HCT-116 colon cancer cells under proton beam radiotherapy. Results: It was found that the ROS in the presence of Cis at 3 Gy of radiation dose was the highest, followed by BC, BiONPs, BB, BRF, and BCB treatments. The properties of bismuth as a radical scavenger, as well as the BRF as a natural compound, might contribute to the lower intracellular ROS induction. The ROS in the presence of Cis and BC combination were also time-dependent and radiation dose-dependent. Conclusions: As the prospective alternatives to the Cis, the BC combination and individual BiONPs showed the capacities to be developed as radiosensitizers for proton beam therapy.

Słowa kluczowe

EN

ROS; bismuth oxide nanoparticles; cisplatin; proton

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2022
• Tom: Vol. 28, Iss. 1
• Strony: 30--36
• Opis fizyczny: Bibliogr. 44 poz., rys., tab.

Twórcy

autor

Sisin Noor Nabilah Talik

• School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

• https://orcid.org/0000-0003-1054-6173

autor

Akasaka Hiroaki

• Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe, Japan

autor

Sasaki Ryohei

• Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe, Japan

autor

Tominaga Takahiro

• Faculty of Health Sciences, Hiroshima International University, Hiroshima, Japan

autor

Miura Hayato

• Hyogo Ion Beam Medical Centre, Hyogo, Japan

autor

Nishi Masashi

• Hyogo Ion Beam Medical Centre, Hyogo, Japan

autor

Geso Moshi

• Medical Radiation Discipline, School Medical Sciences, RMIT University, Victoria, Australia

autor

Mat Nor Fazila Che

• School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

autor

Razak Khairunisak Abdul

• School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Penang, Malaysia

autor

Rahman Wan Nordiana

• School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).