2,3-dihydro-quinazolin-4(1H)-one as a fluorescent sensor for Hg2+ ion and its docking studies in cancer treatment

• Autorzy: Mohhamadi Ziarani Ghodsi , Tahmasebi Ashtiani Shadi , Mohajer Fatemeh , Badiei Alireza , Gaikwad Sunil V. , Varma Rajender S.

Identyfikatory

DOI

10.2478/cdem-2022-0004

• Języki publikacji: EN

Abstrakty

EN

The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO3H and its application was explored as a highly selective fluorescent sensor for Hg2+ ion; fluorescence intensity was decreased selectively by Hg2+ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg2+ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.

Słowa kluczowe

EN

2,3-dihydro-quinazolin-4(1H)-one; fluorescent sensors; SBA-Pr-SO3H; Hg2+ ion; sensors

PL

2,3-dihydro-quinazolin-4(1H)-one; sensory fluorescencyjne; SBA-Pr-SO3H; jon Hg2+; sensory

• Wydawca: Towarzystwo Chemii i Inżynierii Ekologicznej
• Czasopismo: Chemistry-Didactics-Ecology-Metrology
• Rocznik: 2022
• Tom: R. 27, NR 1-2
• Strony: 25--33
• Opis fizyczny: Bibliogr. 38 poz., rys., wykr.

Twórcy

autor

Mohhamadi Ziarani Ghodsi

• Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran; P.O. Box: 1993893973, phone/fax [phone]

• https://orcid.org/0000-0001-5177-7889

autor

Tahmasebi Ashtiani Shadi

• Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran; P.O. Box: 1993893973, phone/fax [phone]

• https://orcid.org/0000-0001-5101-1971

autor

Mohajer Fatemeh

• Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran; P.O. Box: 1993893973, phone/fax [phone]

• https://orcid.org/0000-0003-0587-2230

autor

Badiei Alireza

• School of Chemistry, College of Science, University of Tehran, Tehran, Iran

• https://orcid.org/0000-0002-6985-7497

autor

Gaikwad Sunil V.

• Department of Chemistry, Dr. D. Y. Patil ACS Women’s College Pimpri Pune-411018; Affiliation to Savitribai Phule Pune University, Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia

• https://orcid.org/0000-0003-0754-1945

autor

Varma Rajender S.

• Regional Center of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Slechtitelu, Olomouc, Czech Republic

• https://orcid.org/0000-0001-9731-6228

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).