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Tytuł artykułu

HPLC determination of K027 in the body of pregnant mice

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses’ brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses’ brains relative to its levels in the mothers’ plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.
Rocznik
Strony
85--93
Opis fizyczny
Bibliogr. 30 poz., rys., tab.
Twórcy
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
  • COMSATS Institute of Information Technology, Park Road, Islamabad, Pakistan
autor
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
autor
  • Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
autor
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
autor
  • Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
autor
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
autor
  • Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
  • Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Bibliografia
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  • [4] G.A. Petroianu, S.M. Nurulain, N. Nagelkerke, M.A. Al-Sultan, K. Kuca, and J. Kassa, J. Appl. Toxicol., 26, 262 (2006)
  • [5] G.A. Petroianu, M.Y. Hasan, S.M. Nurulain, N. Nagelkerke, J. Kassa, and K. Kuca, Toxicol. Mech. Methods, 17, 401 (2007)
  • [6] S.M. Nurulain, Trop. J. Pharm. Res., 10, 341 (2011)
  • [7] K. Kuca, J. Bielavsky, J. Cabal, and M. Bielavska, Tetrahedron Lett., 44, 3123 (2003)
  • [8] K. Kuca and J. Cabal, Cent. Eur. J. Public Health, 12 Suppl, S59 (2004)
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  • [11] K. Kuca, L. Sevelová-Bartosová, and G. Krejcova-Kunesova, Acta Medica (Hradec Kralove), 47, 107 (2004)
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  • [13] K. Kuca, K. Musilek, D. Jun, M. Pohanka, K.K. Ghosh, and M. Hrabinova, J. Enzyme Inhib. Med. Chem., 25, 509 (2010)
  • [14] J.Z. Karasova, J. Chladek, M. Hroch, F. Josef, D. Hnidkova, and K. Kuca, J. Appl. Toxicol., 33, 18–23 (2013)
  • [15] J.Z. Karasova, F. Zemek, K. Musilek, and K. Kuca K. Neurotox. Res., 23, 63 (2013)
  • [16] H. Kalász, S.M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi, and K. Tekes, J. Appl. Toxicol., 35, 116 (2015)
  • [17] K. Tekes, M.Y. Hasan, R. Sheen, K. Kuca, G. Petroianu, K. Ludányi, and H. Kalász, J. Chromatogr. A., 1122, 84 (2006)
  • [18] M. Gyenge, H. Kalász, G.A. Petroianu, R. Laufer, K. Kuca, and K. Tekes, J. Chromatogr A., 1161, 146 (2007)
  • [19] T. Csermely, H. Kalász, G. Petroianu, K. Kuca, F. Darvas, K. Ludanyi, A.A. Mudhafar and K Tekes, K. Curr. Med. Chem., 15, 2401 (2008)
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  • [22] H. Kalász, S.M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi, and K. Tekes, J. Appl. Toxicol., 35, 116 (2015)
  • [23] P. Szegi, H. Kalász, R. Laufer, K. Kuca, and K, Tekes, Anal. Bioanal. Chem., 397, 579 (2010)
  • [24] S. Ojha, S.M. Nurulain, S. Dhanasekaran, N. Nalin, A. Adem, C. Sharma, and H. Kalász, Blood-fetus penetration of pralidoxime, submitted for publication (2015)
  • [25] S.M. Nurulain, K. Tekes, S.N.H. Naqvi, C. Sharma, and S. Ojha, Arch Toxicol., 88, 575 (2014)
  • [26] D.E. Lorke, M.Y. Hasan, S.M. Nurulain, R. Sheen, K. Kuca, and G.A. Petroianu, J. Appl. Toxicol., 27, 482 (2007)
  • [27] D.E. Lorke, H. Kalász, G. Petroianu, and K. Tekes, Curr. Med. Chem., 15, 743 (2008)
  • [28] D.E. Lorke, S.M. Nurulain, M.Y. Hasan, K. Kuca, K. Musilek, and G.A. Petroianu, J. Appl. Toxicol., 28, 920 (2008)
  • [29] S.M. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M.Y.B. Hasan, F. Hashemi, and K. Tekes, Acta Chromatogr., 25, 703 (2013)
  • [30] http://www.chemm.nlm.nih.gov/countermeasure_atropine-sulfate.htm
Uwagi
PL
Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-446158f0-e7ce-49f9-9674-0e749ce6965c
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