HPLC determination of K027 in the body of pregnant mice

• Autorzy: Nurulain S. M. , Ojha S. , Dhanasekaran S. , Kuča K. , Nalini N. , Sharma C. , Adem A. , Kalász H.

Identyfikatory

DOI

10.1556/1326.2017.29.1.06

• Języki publikacji: EN

Abstrakty

EN

Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses’ brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses’ brains relative to its levels in the mothers’ plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.

Słowa kluczowe

EN

K027; drug distribution; pregnant mice; pups; blood—placenta distribution; HPLC

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 1
• Strony: 85--93
• Opis fizyczny: Bibliogr. 30 poz., rys., tab.

Twórcy

autor

Nurulain S. M.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
• COMSATS Institute of Information Technology, Park Road, Islamabad, Pakistan

autor

Ojha S.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates

autor

Dhanasekaran S.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates

autor

Kuča K.

• Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic

autor

Nalini N.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates

autor

Sharma C.

• Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

autor

Adem A.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates

autor

Kalász H.

• Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arab Emirates University, Al Ain, United Arab Emirates
• Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).