Synthesis, Characterization and Anti-diabetic activity of 1,3,5-triaryl-2-pyrazolines in acetic acid solution under Ultrasound Irradiation

• Autorzy: Emayavaramban M. , Santhi N. , Gopi C. , Manivannan C. , Raguraman A.
• Języki publikacji: EN

Abstrakty

EN

A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide / semicarbazide hydrochloride / benzhydrazide / benzenesulphonyl hydrazide / phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13CNMR spectral data. All the target compounds were evaluated for their in-vivo anti - diabetic activity in rates in comparison with as reference drug.

Słowa kluczowe

EN

Chalcone; Pyrazoline; ultrasound irradiation; Anti-diabtic activity and Alloxan Monohydrate

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2013
• Tom: Vol. 9, iss. 2
• Strony: 172--185
• Opis fizyczny: Bibliogr. 28 poz., tab., wz.

Twórcy

autor

Emayavaramban M.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Santhi N.

• Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India

autor

Gopi C.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Manivannan C.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

autor

Raguraman A.

• Department of Chemistry, Manonmaniam SundaranarUniversity, Tirunelvel - 627012, Tamil Nadu, India

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