Chitosan-based nanocomposites as potential materials for nerve regeneration

• Autorzy: Turek A. , Dudziński K. , Stodolak-Zych E.
• Konferencja: 24th Conference on Biomaterials in medicine and veterinary medicine : 9--12 October 2014, Rytro, Poland
• Języki publikacji: EN

Abstrakty

EN

The nanocomposite material based on chitosan was obtained and characterized. Commercially produced biopolymer at 85% deacetylization degree was used. The biopolymer matrix was modified with carbon nanofillers such as graphite oxide (GO), carbon nanotubes (CNTs) and nanontubes with the surface affected by carboxyl groups (CNT-COOH). The obtained nanocomposites were formed by means of two methods: casting (to manufacture nanocomposite foils) and liofilization (to manufacture porous nanocomposite materials). Their electrical properties and microstructure were examined. The tests proved that adding the carbon nano-filler results in high resistivity (graphite foils, carbon nanotubes) and also the average size of pores in liofilized materials. Additionally, the electric potential of the materials may be improved by surface processing (EPD- electrophoretic deposition). The described materials are an alternative to polymer nerve implants e.g. tubes or hydrogels which are already present on the market and applied to regenerate nerves.

Słowa kluczowe

EN

nanocomposites; chitosan; carbon fillers; guided nerve regeneration (GNR)

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2014
• Tom: Vol. 17, no. 128-129
• Strony: 86--87
• Opis fizyczny: Bibliogr. 2 poz., tab., zdj.

Twórcy

autor

Turek A.

• AGH University of Science and Technology, 30 A.Mickiewicza Ave., 30-059 Krakow, Poland, Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering

autor

Dudziński K.

• AGH University of Science and Technology, 30 A.Mickiewicza Ave., 30-059 Krakow, Poland, Faculty of Mechanical Engineering and Robotics

autor

Stodolak-Zych E.

• AGH University of Science and Technology, 30 A.Mickiewicza Ave., 30-059 Krakow, Poland, Faculty of Materials Science and Ceramics

Bibliografia

• [1] K. Haastert-Talini, S. Geuna, L. B. Dahlin, C. Meyer, L. Stenberg at all, Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects Biomaterials, Vol 34, Issue 38, 2013, 9886–9904
• [2] F.Sun, X. Pang, I. Zhitomirski, Electrophoretic deposition of composite hydroxyapatite chitosane heparine coatings, Journal of materials processing technology, Vol 209, 2009, p 1597-1606