Feasibility study of positronium application for blood clots structural characteristics

• Autorzy: Moyo Simbarashe , Moskal Paweł , Stępień Ewa Ł.

Identyfikatory

DOI

10.2478/bioal-2022-0087

• Konferencja: 4th Jagiellonian Symposium on Advances in Particle Physics and Medicine, Krakow, 10-15 July 2022
• Języki publikacji: EN

Abstrakty

EN

Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material's microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material's properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.

Słowa kluczowe

EN

PALS; thrombus; fibrin clot; positronium; biomarker; PET

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2022
• Tom: Vol. 18, no. 1
• Strony: 163--167
• Opis fizyczny: Bibliogr. 19 poz., rys.

Twórcy

autor

Moyo Simbarashe

• Department of Medical Physics, M. Smoluchowski Institute of Physics; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University ul. Łojasiewicza 11, 30-348 Kraków, Poland

autor

Moskal Paweł

• Center for Theranostics, Jagiellonian University ul. Kopernika 40, 31-034 Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland
• Department of Experimental Particle Physics and Applications, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11 St, 30-348 Krakow, Poland

autor

Stępień Ewa Ł.

• Department of Medical Physics, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University ul. Łojasiewicza 11, 30-348 Kraków, Poland
• Center for Theranostics, Jagiellonian University ul. Kopernika 40, 31- 034 Kraków, Poland
• Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, Kraków, Poland

Bibliografia

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Uwagi

Opublikowane przez Sciendo. Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).