HPLC analysis and detection of l-deprenyl

• Autorzy: Csomor V. , Laufer R. , Pöstényi Z. , Kalász H. , Adeghate E. , Nurulain S. M. , Tekes K. , Adem A.
• Języki publikacji: EN

Abstrakty

EN

l-Deprenyl and its major metabolites were subjected to reversed-phase high-performance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected l-deprenyl, l-nordeprenyl, l-methamphetamine, and l-amphetamine. Amperometric detection was specific and sensitive to the parent compound (l-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

Słowa kluczowe

EN

l-deprenyl; HPLC; amperometric detection; UV detection; metabolites

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2014
• Tom: Vol. 26, no. 4
• Strony: 649--656
• Opis fizyczny: Bibliogr.15 poz., rys., tab.

Twórcy

autor

Csomor V.

• Semmelweis University Department of Pharmacodynamics Budapest Hungary

autor

Laufer R.

• Semmelweis University Department of Pharmacodynamics Budapest Hungary
• Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary

autor

Pöstényi Z.

• Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary

autor

Kalász H.

• Semmelweis University Department of Pharmacology and Pharmacotherapy Budapest Hungary

autor

Adeghate E.

• United Arab Emirates University Department of Anatomy Al Ain UAE

autor

Nurulain S. M.

• United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE

autor

Tekes K.

• Semmelweis University Department of Pharmacodynamics Budapest Hungary

autor

Adem A.

• United Arab Emirates University Department of Pharmacology and Therapeutics Al Ain UAE

Bibliografia

• [1] L. Brunton, B. Chabner, and B. Knollman (Eds) Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th edn, McGraw Hills, New York, 2011
• [2] www.drugbank.ca
• [3] J. Knoll, Exp. Gerontol., 32, 539 (1997)
• [4] G. Szebeni, J. Lengyel, G. Székács, K. Magyar, J. Gaál, and I. Szatmári, Acta Physiol Hung., 83, 135 (1995)
• [5] Z. Tarjányi, H. Kalász, G. Szebeni, I. Hollósi, M. Báthori, and S. Fürst, J. Pharm. Biomed. Anal., 17, 725 (1998)
• [6] K.S. Patrick, B.L. Nguyen, and J.D. McCallister, J. Chromatogr., 583, 254 (1992)
• [7] D. Háberle, H. Kalász, I. Hollósi, J. Pucsok, T. Csermely, K. Magyar, and E. Tóth-Molnár, Chromatographia, 50, 415 (1999)
• [8] R. La Croix, P. Dostert, and M. Strolin Benedetti, J. Chromatogr., B. Biomed. Appl., 681, 185 (1996)
• [9] Z. Tarjányi, H. Kalász, I. Hollósi, M. Báthori, T. Bartók, J. Lengyel, K. Magyar, and S. Fürst, Eur. J. Drug Metab. Pharmacokinet., 23, 324 (1998)
• [10] J. Lengyel, K. Magyar, I. Hollósi, T. Bartók, M. Báthori, H. Kalász, and S. Fürst, J. Chromatogr., A. 762, 321 (1997)
• [11] H. Kalász, T. Bartók, É. Szökó, D. Háberle, J.P. Kiss, E.C. Hennings, K. Magyar, and S. Fürst, Curr. Med. Chem., 6, 271 (1999)
• [12] M. Katagi, M. Tatsuno, A. Miki, M. Nishikawa, K. Nakajima, and H. Tsuchihashi, J. Chromatogr., B: Biomed. Sci. Appl., 759, 125 (2001)
• [13] É. Szökó, H. Kalász, and K. Magyar, Eur. J. Drug Metab. Pharmacokinet., 24, 315 (1999)
• [14] E.M. Kim, H.S. Chung, K.J. Lee, and H.J. Kim, J. Anal. Toxicol., 24, 238 (2000)
• [15] H. Kalász, P. Szegi, G. Jánoki, L. Balogh, Z. Pöstényi, K. Musilek, G.A. Petroianu, A. Siddiq, and K. Tekes, Curr. Med. Chem., 20, 2137 (2013)