Fabrication of novel material with athrombogenic potential: Immobilization of peptides on polyurethane surface

• Autorzy: Ziętek P. , Butruk B. , Ciach T.
• Języki publikacji: EN

Abstrakty

EN

Presented study was undertaken to fabricate a hemocompatible material that could be a potential candidate for use in fabrication of blood-contacting devices, e.g. circulatory support devices, vessel grafts, heart valves. The final material could be used as a scaffold for endothelial cell growth and initiate in situ endothelialisation. The newest and most promising strategy in material endothelialization involves introduction of short peptide sequences that can selectively address one particular type of cell adhesion receptors and promote cell adhesion. Thus, the aim of work was to elaborate a method of immobilizing peptides specific for integrins onto polymer substrate.

Słowa kluczowe

EN

polyurethane; endothelium; peptides immobilization

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2012
• Tom: Vol. 3, no. 1
• Strony: 38--41
• Opis fizyczny: Bibliogr. 12 poz., rys., wykr.

Twórcy

autor

Ziętek P.

• Warsaw University of Technology, Faculty of Chemical and Process Engineering, ul. Waryńskiego 1, 00-645 Warszawa

autor

Butruk B.

autor

Ciach T.

Bibliografia

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• [6] Pawlowski, K.J., et al. “Endothelial cell seeding of polymeric vascular grafts”. Frontiers in Biosciences 9 (2004): 1412–1421.
• [7] Pierschbacher, M., E.G. Hayman and E. Ruoslaht. “Synthetic peptide with cell attachment activity of fi bronectin” Proceedings of the National Academy of Sciences of USA 80 (1983): 1224–1227.
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• [9] Ignacio, C., I.A.S. Gomes, and R.L. Oréfi ce. “Polyurethane membranes with tunable surface properties for biomedical applications”. Journal of Applied Polymer Science (2011), in press.
• [10] Ma, Z., et al. “Immobilization of Natural Macromolecules on Poly-L-Lactic Acid Membrane Surface in Order to Improve Its Cytocompatibility”. Journal of Biomedical Materials Research 63.6 (2002): 838–847.
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