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Toxicity evaluation of exhaust gases in diesel engines using toxicological methods

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Języki publikacji
EN
Abstrakty
EN
Diesel engines, due to dynamics occurring during the combustion process of thermodynamic phenomena, are one of the most important sources of anthropogenic emissions of carcinogens, accumulating in the environment of organic substances (primarily polycyclic aromatic hydrocarbons and solid nano- and microparticles). According to the latest reports, they determine the toxicity of exhaust gases, and the number of victims of lifestyle diseases that they cause now exceeds the number of casualties resulting from road accidents. To assess the risks resulting out of these hazardous compounds into the environment analyzers of particulate matter, FID an alyzers gas chromatography methods with mass detection are currently used (for the purpose of qualitative and quantitative analysis hydrocarbons). The analyzers mentioned above are expensive, beside chromatographic methods require pre-emptive phases, compacting and extracting samples that are subject to certain errors. Additionally, the end result - quality-quantity composition of organic matter in exhaust gases, gives us relatively little information about their actual impact on human health or the health of ecosystems, because such an answer can only be obtained by means of toxicological studies - taking into account the definition of not only the nature of substance inducing a negative effect on the body but also the manner of its penetration to interior and the time of exposure to its action. This study evaluated the possibility and purposefulness of toxicological methods as an alternative to expensive and labor-intensive conventional chemical analyzes.
Rocznik
Strony
91--103
Opis fizyczny
Bibliogr. 30 poz., rys., fot., tab.
Twórcy
autor
  • Politechnika Wrocławska Wydział Mechaniczny Katedra Inżynierii Pojazdów Wyb. Wyspiańskiego 27 50-370 Wrocław Tel/fax +48 71 3477918
Bibliografia
  • [1] Bihari N., Fafandel M., Hamer B., Kralj-Bilen B.: PAH content, toxicity and genotoxicity of coastal marine sediments from the Rovinj area, Northern Adriatic, Croatia Science of the Total Environment 366 (2006) 602–611
  • [2] Borma P. , Cakmakb G., Jermannc E., Weishaupta C., Kempersd P., Schootend F., oberdorstere G., Schinsar.: Formation of PAH–DNA adducts after in vivo and vitro exposure of rats and lung cells to different commercial carbon blacks. Toxicology and Applied Pharmacology 205 (2005) 157 – 167
  • [3] Pandey M.K., Pant A.B, Das M.: In vitro cytotoxicity of polycyclic aromatic hydrocarbon residues arising through repeated Wsh fried oil in human hepatoma Hep G2 cell line. Toxicology in Vitro 20 (2006) 308–316
  • [4] Lebrecht G., Czerczak S., Szymczak W.: Benzen – dokumentacja. SzymczakPodstawy i Metody Oceny Środowiska Pracy Numer 1 (35) 2003
  • [5] Mendyka B., Radek P., Wargacka A., Czarny A., Zaczyńska E., Pawlik M.: Cytotoksyczność i mutagenność preparatów zawierających domieszkę estru metylowego oleju rzepakowego, Medycyna Środowiskowa 2005;8 (2)
  • [6] Materiały z serwisu Centralnego Instytutu Ochrony Pracy – Państwowy Instytut Badawczy http://www.ochronapracy.pl/6558.html 14 luty 2008r.,
  • [7] Prawo ochrony środowiska, ustawa z dnia 27 kwietnia 2001 r., Dz. U. 2001. 62.627.
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  • [9] Janicka A. Method of toxicity estimation of gaseous mixtures emitted from different emission sources: Polish Journal of Environmental Studies. Vol. 21, No 5A, (2012)
  • [10] Janicka A., In-vehicle toxicity measurements: in-vitro tests as a new method of toxicological estimation of car cabin atmosphere. Proceedings of ECOpole. (2013), vol. 7, nr 1, s. 93-99.
  • [11] Janicka A., Zawiślak M., Czarny A., Zaczyńska E., Numerical modelling application for developing of vehicle interior toxicity estimation (in-vitro tests) methodology. Systems: Journal of Transdisciplinary Systems Science (2012), vol. 16, nr 2, s. 9-15.
  • [12] Janicka A.: Emisja związków toksycznych z silnika o zapłonie samoczynnym z katalizatorem wewnętrznym. Raporty Inst. Inż. Ochr. Śr. PWroc. 2008, Ser. PRE nr 3
  • [13] Janicka A. Ocena toksyczności mikroatmosfery środowiska wnętrza pojazdu samochodowego. Wrocław : Oficyna Wydawnicza Politechniki Wrocławskiej, 2013.
  • [14] Fisher T., Law R., Rumney H., Kirby M., Kelly C., Towards a scheme of toxic equivalency factors (TEFs) for the acute toxicity of PAHs in sediment, Ecotoxicology and Environmental Safety, Volume 74, Issue 8,( November 2011), Pages 2245-2251
  • [15] Manahan S.E.: Toksykologia Środowiska, Wydawnictwo Naukowe PWN, Warszawa (2006). (tytuł oryginalny Toxicological Chemistry and Biochemistry, third edition CRS Press LLC 2003)
  • [16] Czarny A, Zaczyńska E, Mendyka B., Janicka A.: Influence of biodiesel exhaust on NF-kB activation and TNF-α production in.human lung and peripheral blood leukocytes, in vitro. Materiały Konnferencyjne IV Konferencja Naukowo-Szkoleniowa ”Immunomodulacja: badania doświadczalne i kliniczne”. Jurata, Polska, 25.05.-26.05 (2007)
  • [17] Aufderheide M., Ritter D., Knebel J. W., Scherer G., A method for in vitro analysis of the biological activity of complex mixtures such as sidestream cigarette smoke, Exp Toxic Pathol (2001); 53: 141–152
  • [18] Kleinn S, Department of Environmental Toxicology, University Trier, Germany (2013) June 30 January 2013 )
  • [19] Adamson J, British American Tobacco, Group R&D, Southampton SO15 8TL, UK (2013)
  • [20] Anderson S.E., Khurshid S.S., Meade B.J., Lukomska E., Wells J.R. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States. Toxicology In Vitro. (2012) Dec 7;27(2):721-73
  • [21] Wolza L., Krausea G., Scherera G., Aufderheideb M., U. Mohrb,In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line, Food and Chemical Toxicology 40 (2002) 845–850
  • [22] Aufderheide M., Knebel J., Ritte D.,An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke, Exp Toxic Pathol (2003), 55, 51-57
  • [23] Materiały dostępne na stronie: www.vitrocell.com
  • [24] Steiner S., Czerwinski J., Comte P., Popovicheva O., Kireeva E., Müller L., Heeb N., Mayer A., Fink A., Rothen-Rutishauser B., Comparison of the toxicity of diesel exhaust produced by bio- and fossil diesel combustion in human lung cells in vitro; Atmospheric Environment, In Press, Accepted Manuscript, Available online 21 September 2013
  • [25] Sandro S., Czerwinski J., Comte P, Müller L,, Heeb N., Mayer A., Petri-Fink A, Rothen-Rutishauser B. Reduction in (pro-)inflammatory responses of lung cells exposed in vitro to diesel exhaust treated with a non-catalyzed diesel particle filter, Atmospheric Environment 81 (2013) 117-124
  • [26] Steinera S., Mueller L., Popovicheva O., Raemy D., Czerwinski J. Comte P., Mayer A., Gehr P., Rothen-Rutishauser B., Clift M., Cerium dioxide nanoparticles can interfere with the associated cellular mechanistic response to diesel exhaust exposure Atmospheric Environment 81 (2013) 117-124
  • [27]Jackson G., Armento A., Letasiova S., Hayden P. Klausner M.,Rapid Toxicity and Drug Delivery Screening in an in vitro Human Airway Model; MatTek Corporation, Ashland, Massachusetts – USA, Presented at EuroTox 2013, Interlaken, Switzerland, EuroTox (2013) Poster P07-25
  • [28] Mueller L., Comte P., Popovicheva O., Czerwinski J., Mayer A., Rothen-Rutishauser B., Clift M New Exposure System To Evaluate the Toxicity of (Scooter) Exhaust Emissions in Lung Cells in Vitro, Environ. Sci. Technol. (2010), 44, 2632–2638
  • [29] Jackson G., Armento A., Letasiova S., Hayden P. Klausner M., Rapid Toxicity and Drug Delivery Screening in an in vitro Human Airway Mode;l MatTek Corporation, Ashland, Massachusetts – USA, Presented at EuroTox 2013, Interlaken, Switzerland, EuroTox 2013 Poster P07-25,
  • [30] Liu F., Peng C., Escher B., Fantino E., Giles C., Were S., Duffy J., An in vitro air toxic exposure model using human lung cells in 2D and 3D structures; Journal of Hazardous Materials, In Press, Corrected Proof, (available online 30 January 2013)
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-3de47459-c9e3-42dc-bf14-1f86d861f635
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