Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature

• Autorzy: Qiao H. , Zhao H. , Jaron D.

Identyfikatory

DOI

10.1016/j.bbe.2016.10.004

• Języki publikacji: EN

Abstrakty

EN

Aggregation of red blood cells in the micro vasculature may affect blood viscosity in the vessel. The purpose of this study was to investigate the potential effect of non-uniform viscosity caused by red blood cell (RBC) aggregation on nitric oxide (NO) concentration and distribution. A 3-D multi-physics model was established to simulate the production, transport and consumption of NO. Two non-uniform viscosity models caused by RBC aggregation were investigated: one assuming a linear and the other a step hematocrit distribution. In addition, the effect of the thickness of the plasma layer was tested. Simulation results demonstrate that non-uniform viscosity caused by RBCs aggregation influences NO concen-tration distribution. Compared with the uniform viscosity model, NO concentration using non-uniform viscosity is lower than that using uniform viscosity. Moreover, NO concentration calculated from the step hematocrit model is higher than that calculated from the linear hematocrit model. NO concentrations in the endothelium and the vascular wall decrease with the decline of the thickness of the plasma layer. The relative decrease differs between the linear and the step model. Our results suggest that non-uniform viscosity caused by red blood cell aggregation affects nitric oxide distribution in the micro vasculature. If uniform viscosity is assumed when performing numerical simulations, NO concentration values may be overestimated.

Słowa kluczowe

EN

nitric oxide; microvasculature; blood viscosity; numerical simulation

PL

tlenek azotu; mikrounaczynienie; lepkość krwi; symulacja numeryczna

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2017
• Tom: Vol. 37, no. 3
• Strony: 341--346
• Opis fizyczny: Bibliogr. 21 poz., rys., tab., wykr.

Twórcy

autor

Qiao H.

• Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

autor

Zhao H.

• Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

autor

Jaron D.

• School of Biomedical Engineering, Science and Health Systems, Drexel University, United States

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).