Determination of the Dexlansoprazole in Bulk and Spiked Human Plasma by Extraction Spectrophotometry

• Autorzy: Sekharan C. B. , Rao M. P. , Mahesh M. , Chandramouli I. , Seemanth J.

Identyfikatory

DOI

10.18052/www.scipress.com/ILCPA.52.28

• Języki publikacji: EN

Abstrakty

EN

This paper describes a simple extraction spectrophotometric method for the quantification of dexlansoprazole in bulk and spiked human plasma. This method involves formation of stable yellow colored chloroform extractable ion-pair complex of the amino derivative of dexlansoprazole with acid dye, namely methyl orange in acidic medium. The ion-pair complexes exhibit absorption maxima at 425 nm. Dexlansoprazole can be determined up to 4-40 μg/mL by the proposed method. The effect of optimum reagent concentration was studied. The relative standard deviations (≤1. 246%) obtained in the intra-day and inter-day analyses were found to be satisfactory. The accuracy results exhibited the mean recovery and percentage error in the range of 99.137%–100.574% and 0.012%–0.863%. When applied for the assay of the dexlansoprazole in spiked human plasma sample, recovery mean values ranged from 96.495–98.960%. The proposed method is useful for the estimation of the dexlansoprazole in bulk and human plasma samples.

Słowa kluczowe

EN

Dexlansoprazole; methyl orange; spectrophotometry; Spiked Plasma Sample

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2015
• Tom: Vol. 52
• Strony: 28--38
• Opis fizyczny: Bibliogr. 17 poz., rys., wz.

Twórcy

autor

Sekharan C. B.

• Department of Pharmaceutical Biotechnology and Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601.

autor

Rao M. P.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Mahesh M.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Chandramouli I.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

autor

Seemanth J.

• Department of Pharmaceutical analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India - 522 601

Bibliografia

• [1] Davies S.L., Drugs Today (Barc). 46 (2010) 75.
• [2] Welage L.S., Pharmacotherapy. 23 (2003) 74S.
• [3] FDA Approves KAPIDEX (dexlansoprazole) delayed release capsules for the Treatment of GERD., http://www.takeda.com/press/article_32521.html.
• [4] Katsuki H, Yagi H, Arimori K, Nakamura C, Nakano M, Katafuchi S, Fujioka Y, Fujiyama S., Pharmaceut Res. 13 (1996) 611.
• [5] Borner K, Borner E, Lode H., Chromatographia. 47 (1998) 171.
• [6] Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M., J Chromatogr B Biomed Sci Appl. 757 (2001) 127.
• [7] Miura M, Tada H, Suzuki T., J Chromatogr B. 804 (2004) 389.
• [8] Gomes R.F, Cassiano N.M, Pedrazzoli J.Jr, Cass Q.B., Chirality. 22 (2010) 35.
• [9] Kishore Kumar H, Bharathi D.V, Jagadeesh B, Ravindranath L.K, Jaya Veera K.N, Venkateswarulu V., Biomed Chromatogr. 26 (2012) 192.
• [10] Geetharam Y, Praveen srikumar P, Rushyendra G.V, Ramamohanupta V, Srinivasarao S., Indo American J Pharm Res. 3(2013) 8457.
• [11] Yarwood J, ed., Spectrosccopy and Structure of Molecular Complexes, Plenum Press, London, 1973.
• [12] Foster R, ed., Molecular complexe, Vol.I, (1973) and Vol. II (1974), Elek Science, London.
• [13] Rahman N, Siddiqui S, Azmi S.N.H., AAPS PharmSciTech. 10 (2009) 1381.
• [14] Rahman N, Khatoon A, Rahman H., Química Nova. 35 (2012) 392.
• [15] Rajiv C, Kumar A, Anju G., J Pharm Bioallied Sci. 2 (2010) 365.
• [16] Malek O, Amir Alhaj S, Banana A., Int J Pharm Pharmaceu Sci. 6 (2014) 43.
• [17] Validation of Analytical Procedures; Methodology, International Conference on Harmonization (ICH): Text and Methodology Q2 (R 1): Complementary Guideline on Methodology dated 06 November 1996: incorporated in November 2005, London.