Positronium imaging in J-PET with an iterative activity reconstruction and a multistage fitting algorithm

Shopa, Roman Y.; Dulski, Kamil

doi:10.5604/01.3001.0054.1826

Artykuł - szczegóły

Tytuł artykułu

Positronium imaging in J-PET with an iterative activity reconstruction and a multistage fitting algorithm

Autorzy

Shopa Roman Y. , Dulski Kamil

Wybrane pełne teksty z tego czasopisma

Identyfikatory

DOI

10.5604/01.3001.0054.1826

Warianty tytułu

Języki publikacji

Abstrakty

Positronium imaging is a new technique complementary to positron emission tomography (PET) based on the histogramming of time delay between the emission of a de-excitation photon, and a consequent electron-positron annihilation, to estimate the mean lifetime of orthopositronium (o-Ps), which depends on the local size of the voids, concentration of oxygen and bioactive molecules. We improve the resolution and reduce noise in positronium imaging by building time-delay spectra from the PET activity reconstructed by a 3-photon time-of-flight maximum likelihood expectation maximisation. The method was tested on the data measured for four human-tissue samples injected by 22Na and put in the Jagiellonian PET “Big barrel” scanner. Due to an ill-posed problem of fitting time-delay histograms, a multistage optimisation procedure was explored along with inferential analysis of the solution space. Run in parallel for multiple sets of initial guesses, we compared the second-order LevenbergMarquardt algorithm (LMA) and the direct search Nelder-Mead simplex (NMS) method. The LMA proved to be faster and more precise, but the NMS was more stable with a higher convergence rate. The estimated mean o-Ps lifetimes in the 1.9 ns - 2.6 ns range were consistent with the reference results, while other fitting parameters allowed differentiation between the two patients who provided the tissue samples.

Słowa kluczowe

Jagiellonian PET positronium imaging MLEM ill-posed problem nonlinear optimisation

Wydawca

Uniwersytet Jagielloński - Collegium Medicum
Index Copernicus Sp. z o.o.

Czasopismo

Bio-Algorithms and Med-Systems

Rocznik

2023

Tom

Vol. 19, no. 1

Strony

54--63

Opis fizyczny

Bibliogr. 49 poz., rys., tab.

Twórcy

autor

Shopa Roman Y.

National Centre for Nuclear Research Department of Complex Systems, Otwock-Swierk, Poland

https://orcid.org/0000-0002-1089-5050

autor

Dulski Kamil

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland

https://orcid.org/0000-0002-4093-8162

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-3c17d241-abc9-4beb-aed3-a7fb1d3cd510