Próby aktywowania grupy karboksylowej kwasu 3-amino-1Hpirazolo-5-karboksylowego metodą azydkową

Kusakiewicz-Dawid, A.; Masiekiewicz, E.

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Tytuł artykułu

Próby aktywowania grupy karboksylowej kwasu 3-amino-1Hpirazolo-5-karboksylowego metodą azydkową

Autorzy

Kusakiewicz-Dawid A. , Masiekiewicz E.

Treść / Zawartość

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Warianty tytułu

Attempts of activating carboxylic group of 3-amine-1-Hpyrazole-5-carboxylic acid using azide method

Języki publikacji

PL EN

Abstrakty

Opracowano metodę łączenia 3-acetamido-5-karboksy-1H-pirazolu od C- końca z aminokwasem białkowym, bez konieczności ochrony bocznych grup funkcyjnych pierścienia pirazolowego z wykorzystaniem aktywacji azydkowej. W modelowej reakcji zsyntezowano ester metylowy N-(3-acetamido-5-karbonylo-1H-pirazolo)glicyny.

The method was developed for linking 3-acetamido-5-carboxy-1H-pyrazole with protein amino acid from C-end without necessity to protect side functional groups of pyrazole ring by means of azide activation. In the model reaction N-(3-acetamido-5-carbonyl-1Hpyrazole) glycine methyl ester was synthesized.

Słowa kluczowe

aminopirazol hybrydy peptydowe metoda azydkowa

aminopyrazole peptide hybrids azide method

Wydawca

Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego, ZW CHEMPRESS-SITPChem

Czasopismo

Chemik

Rocznik

2014

Tom

Vol. 68, nr 4

Strony

296--303

Opis fizyczny

Bibliogr.36 poz., rys.

Twórcy

autor

Kusakiewicz-Dawid A.

Anna.Kusakiewicz@uni.opole.pl

Zakład Chemii Organicznej, Wydział Chemii, Uniwersytet Opolski, Opole

autor

Masiekiewicz E.

Zakład Chemii Organicznej, Wydział Chemii, Uniwersytet Opolski, Opole

Bibliografia

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Bibliografia załącznikowa
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Typ dokumentu

Bibliografia

Identyfikator YADDA

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