Exploiting column chemistry for chromatographic separation and quantification of caffeoylquinic acids in Gynura procumbens

• Autorzy: Murugesu Kisantini , Saghir Sultan Ayesh Mohammed , Sadikun Amirin , Khaw Kooi-Yeong , Murugaiyah Vikneswaran

Identyfikatory

DOI

10.1556/1326.2020.00690

• Języki publikacji: EN

Abstrakty

EN

A simple and sensitive high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed by exploiting the benefits of phenyl-hexyl column for the simultaneous determination of mono- and di-caffeoylquinic acids in Gynura procumbens plant samples. An optimal chromatographic separation was achieved by using a mobile phase of acetonitrile: 0.25% acetic acid in water (12.5:78.5, v/v) and detection at 330 nm. The limits of detection (LOD) and quantification (LOQ) for the six caffeoylquinic acid standards were in the range of 0.078–0.653 and 0.259–1.795 μg/mL, respectively. The accuracies of the developed method were in the range of 96.84–103.08%, while the corresponding precisions were between 0 and 2.94% for both within-day and between-day analyses, indicating that the method is repeatable and reliable. The mean recoveries were between 87.08 and 117.83%. The method was successfully applied for quantification of caffeoylquinic acids in G. procumbens plant samples. This is the first study on di-caffeoylquinic acids quantification in G. procumbens. Leaves samples contained higher amount of the caffeoylquinic acids compared to stem samples. Of the compounds, 3,5-dicaffeoylquinic acid was found to be the major compound in almost all G. procumbens samples. The method has advantages such as sensitive ultraviolet (UV) detection, short run time with simple isocratic elution system compared to other methods which involved the use of costly instruments, laborious procedures with long run time and complex gradient system. This method can be further extended for routine quality control and analysis of plants or herbal products containing the caffeoylquinic acids.

Słowa kluczowe

EN

mono-caffeoylquinic acid; di-caffeoylquinic acids; HPLC-UV detection; phenyl-hexyl column; Gynura procumbens

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 2
• Strony: 170--178
• Opis fizyczny: Bibliogr. 34 poz., rys., tab.

Twórcy

autor

Murugesu Kisantini

• Discipline of Pharmaceutical Chemistry, School of Pharmaceuticual Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia

autor

Saghir Sultan Ayesh Mohammed

• Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
• Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan

autor

Sadikun Amirin

• Discipline of Pharmaceutical Chemistry, School of Pharmaceuticual Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia

autor

Khaw Kooi-Yeong

• School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, 47500, Malaysia

autor

Murugaiyah Vikneswaran

• Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia

• https://orcid.org/0000-0003-1768-7577

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).