The use of experimental design in separation science

Dejaegher, B; Vander Heyden, Y

Artykuł - szczegóły

Tytuł artykułu

The use of experimental design in separation science

Autorzy

Dejaegher B , Vander Heyden Y

Wybrane pełne teksty z tego czasopisma

Identyfikatory

Warianty tytułu

Języki publikacji

Abstrakty

In this tutorial, the application of experimental designs in separation science is discussed. Method optimization is often divided into screening and optimization phases. In the screening step, many factors, potentially affecting the separation, are screened to identify those with the largest effects. These are then further examined in an optimization phase, to determine the best separation conditions. After optimizing the method, it should be validated, before use for quantitative purposes. Robustness testing is part of method validation and examines the effects on the responses of small changes in method conditions. During the first phase of method optimization and during robustness testing, so-called screening designs are usually applied, whereas during the second phase of optimization, response-surface designs are often used. In this tutorial, the different steps in the application of both types of design are explained and elaborated with some examples.

Słowa kluczowe

experimental design screening design response-surface design optimization robustness testing

Wydawca

University of Silesia in Katowice
Akademiai Kiado

Czasopismo

Acta Chromatographica

Rocznik

2009

Tom

Vol. 21, no. 2

Strony

161--201

Opis fizyczny

Bibliogr. 54 poz., rys., tab.

Twórcy

autor

Dejaegher B

Vrije Universiteit Brussel — VUB Analytical Chemistry and Pharmaceutical Technology (FABI), Pharmaceutical Institute Laarbeeklaan 103 1090 Brussels Belgium

autor

Vander Heyden Y

yvanvdh@vub.ac.be

Vrije Universiteit Brussel — VUB Analytical Chemistry and Pharmaceutical Technology (FABI), Pharmaceutical Institute Laarbeeklaan 103 1090 Brussels Belgium

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikator YADDA

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