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A reconfigurable electrical stimulator for the needs of multichannel neurobiological experiments

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EN
Abstrakty
EN
The article presents a project of an output stage of the system designed for electrical stimulation of neural cells. The construction proposed is based on an operational amplifier working in a configuration of adjustable current source and is dedicated to the multichannel integrated electronic system destined for neurobiological experiments. The system has been tested in the CMOS 180nm technology and is characterized by a wide range of changes in stimulation currents (3 current ranges: 2 μA, 10 μA, 200 μA), high output impedance (above 20 MΩ), as well as a wide range of an output voltage ± 1.45 V for a ± 1.65 V supply voltage). The stimulator can generate different current patterns thanks to RAM and stimulator control logic employed. The work presents results of the simulations that concern both the scope of adjustments of stimulation currents and their mismatches between stimulation channels. The exemplary current waveforms are also shown.
Twórcy
autor
  • Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, Department of Measurement and Electronics, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland
autor
  • Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, Department of Measurement and Electronics, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Krakow, Poland
Bibliografia
  • [1] V. Nurmikko, et al., “Listening to Brain Microcircuits for Interfacing With External World - Progress in Wireless Implantable Microelectronic Neuroengineering Devices”, Proceedings of the IEEE, 2010, Vol.98, No. 3, pp. 375-388
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  • [4] K. Song, H. Lee, S. Hong, H. Cho, U. Ha, H.-J. Yoo, “A Sub-10 nA DC-Balanced Adaptive Stimulator IC With Multi-Modal Sensor for Compact Electro-Acupuncture Stimulation”, IEEE Transactions on Biomedical Circuits and Systems, Vol. 6, No. 6, December 2012
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  • [6] P. Kmon, P. Grybos, “Energy Efficient Low-Noise Multichannel Neural Amplifier in Submicron CMOS Process”, IEEE Transactions on Circuits and Systems-I: Regular Papers, 2013 vol. 60 no. 7, s. 1764-1775
  • [7] P. Kmon,”Digitally Assisted Neural Recording and Spike Detection Multichannel Integrated Circuit Designed in 180nm CMOS Technology”, Microelectronics Journal, Elsevier, accepted for publication, 2014
  • [8] P. Kmon, A. Drozd, ,,Analizy symulacyjne układów stymulacyjnych pod kątem wykorzystania w wielokanałowych układach scalonych”, Pomiary, Automatyka, Kontrola, 2013 vol. 59 nr 3, s. 243-246
  • [9] R. Merrill, M. Bikson, J. G.R. Jefferys, “Electrical stimulation of excitable tissue: design of efficacious and safe protocols”, Journal of Neuroscience Methods 141 (2005) 171-198
  • [10] X. F. Wei, W. M. Grill, “Impedance characteristics of deep brain stimulation electrodes in vitro and in vivo”, Neural Eng. 2009 August; Vol. 6(4)
  • [11] B. Gosselin, “Recent Advances in Neural Recording Microsystems”, Sensors 2011, Vol. 11
  • [12] S. K. Arfin, R. Sarpeshkar, “An Energy-Efficient, Adiabatic Electrode Stimulator With Inductive Energy Recycling and Feedback Current Regulation”, IEEE Transactions on Biomedical Circuits and Systems, Vol. 6, No. 1, February 2012
  • [13] http://www.blackrockmicro.com/
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Bibliografia
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bwmeta1.element.baztech-3b05e9cb-4b9a-405f-b8de-86af79bb6772
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