Synthesis and characterization of 1,3,5-trisubstituted pyrazoline derivatives by ultrasonic irradiation method and evaluation of its antibacterial activity

• Autorzy: Raguraman A. , Santhi N.
• Języki publikacji: EN

Abstrakty

EN

A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, 1HNMR and 13C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.

Słowa kluczowe

EN

4-methylacetophenone; ultrasonic irradiation; chalcone; 2-pyrazoline; antibacterial; antifungal

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 20, iss. 2
• Strony: 219--233
• Opis fizyczny: Bibliogr. 21 poz., rys., tab., wz.

Twórcy

autor

Raguraman A.

• Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India

autor

Santhi N.

• Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India

Bibliografia

• [1] Bandgar B.P et al, Bioorg. Med. Chem 17 (2009) 8168-8173.
• [2] Zeba N.S et al, Bioorg. Med. Chem. Lett 21 (2011) 2860-2865.
• [3] Baraldi P.G et al, Nucleosides Nucleotides Nucleic Acids 17 (1998) 2165-2173.
• [4] Bhat B.A et al, Bioorg. Med. Chem. Lett 15 (2005) 3177-3180.
• [5] Baraldi P.G et al, Bioorg. Med. Chem 11 (2003) 4161-4169.
• [6] Zitouni G.T, Chevallet P, Kiliç F.S., Erol, K. Eur. J. Med. Chem 35 (2000) 635-641.
• [7] Palaska E et al, Eur. J. Med. Chem 36 (2001) 539-543.
• [8] Li J et al, Beilstein J. Org. Chem 3 (2007) 1 4.
• [9] Saleh T.S et al, Ultrason. Sonochem 19 (2012), 491
• [10] Pinto D. J. P et al, J. Med. Chem 44 (2001) 566‐578.
• [11] Wong P. C, Pinto D. J. P., Knabb R. M, Cardiovasc. Drug. Rev 20 (2002) 137‐152.
• [12] Balbi A et al, Bioorg. Med. Chem 14 (2006) 5152‐5160.
• [13] Ge M, Cline E and Yang, L, Tetrahedron Lett 47 (2006) 5797‐5799.
• [14] Sakya S. M, Rast B, Tetrahedron Lett 44 (2003) 7629‐7632.
• [15] Bonacorso H. G et al, J. Braz. Chem. Soc 16 (2005) 868‐873.
• [16] Selvis S., Perumal P. T., J. Heterocycl. Chem 39 (2002) 1129‐1150.
• [17] McQuaid A. L, J. Med. Chem, 35 (1992) 3319‐3324.
• [18] Soleiman H. A, Khalafallah, A. K Abd‐Ellatif H., Eur. J. Chem. 3(3) (2012) 287‐292.
• [19] Parikh, “Absorption spectroscopy of organic molecule”, Addition Wesley Pub. Co. London, (1978) 243.
• [20] Mishtry, A hand book of spectroscopic data., And Press jaipur 47 (2000) 11-36.
• [21] Microbiological assays and tests, Indian Pharmacopoeia, Ministry of Health and Family Welfare, The Controller of Publications, New Delhi.,1996, A-100.