Pharmacokinetics of palmatine in rat after oral and intravenous administration by UPLC-MS/MS

• Autorzy: Li Jianbo , Hu Yujie , Wu Yajin , Feng Tiantian , Wen Congcong , Jiang Xiajuan

Identyfikatory

DOI

10.1556/1326.2020.00712

• Języki publikacji: EN

Abstrakty

EN

Palmatine is a compound with good water solubility extracted from Coptis chinensis, Fibraurea recisa Pierre, Cortex Phellodendri Chinensis. Palmatine has good antibacterial activity and mainly used for the treatment of bacterial dysentery, gynecological inflammation, surgical infection, and conjunctivitis. It has anti-diabetic, anti-oxidant, and cognitive-enhancing activities. In this study, we used UPLC-MS/MS to determinate palmatine in rat plasma, and investigated its pharmacokinetics. Coptisine was utilized as an internal standard (IS), and acetonitrile precipitation method was used to process the plasma samples. Chromatographic separation was achieved using a UPLC BEH C18 column using mobile phase of acetonitrile- 0.1% formic acid with gradient elution. Electrospray ionization (ESI) tandem mass spectrometry in multiple reaction monitoring (MRM) mode with positive ionization was applied. The results indicated that within the range of 1–500 ng/mL, linearity of palmatine in rat plasma was acceptable (r > 0.995), and the lower limit of quantification (LLOQ) was 1 ng/mL. Intra-day and inter-day precision RSD of palmatine in rat plasma were less than 14%. Accuracy range was between 93.7 and 107.1%, and matrix effect was between 101.6 and 109.4%. The method was successfully applied in the pharmacokinetics of palmatine in rats after oral and intravenous administration. The absolute bioavailability of the palmatine was 15.5% in rats.

Słowa kluczowe

EN

palmatine; pharmacokinetics; bioavailability; rat; UPLC-MS/MS

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2021
• Tom: Vol. 33, no. 1
• Strony: 25--29
• Opis fizyczny: Bibliogr. 35 poz., rys., tab.

Twórcy

autor

Li Jianbo

• The Second Affiliated Hospital Zhejiang University School of Medicine Yuhang Campus, Hangzhou, China

autor

Hu Yujie

• Laboratory Animal Centre, Wenzhou Medical University, Wenzhou, China

autor

Wu Yajin

• Laboratory Animal Centre, Wenzhou Medical University, Wenzhou, China

autor

Feng Tiantian

• Laboratory Animal Centre, Wenzhou Medical University, Wenzhou, China

autor

Wen Congcong

• Laboratory Animal Centre, Wenzhou Medical University, Wenzhou, China

autor

Jiang Xiajuan

• The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).