Synthesis, computational, anticancerous and antiproliferative effects of some copper, manganese and zinc complexes with ligands derived from symmetrical 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl-salicylaldehyde

• Autorzy: Ababneh Taher S. , El-Khateeb Mohammad , Tanash Aissar K. , AL-Shboul Tareq M.A. , Shammout Mohammad Jamal A. , Jazzazi Taghreed M.A. , Alomari Mohammad , Daoud Safa , Talib Wamidh H.

Identyfikatory

DOI

10.2478/pjct-2021-0002

• Języki publikacji: EN

Abstrakty

EN

Four new symmetrical Schiff bases derived from 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl-salicylaldehyde have been synthesized and characterized by elemental analysis and different spectroscopic techniques. The reaction of 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl with two equivalents of 5-tert-butyl-, 3,5-dinitro-, 3,5-dibromo- and 3-tert-butyl-salicylaldehyde yielded 2,2’-bis(5-tert-butyl-salicylideneamino)-4,4’-dimethyl-1,1’-biphenyl (A1) as well as the 3,5-dinitro- (A2), 3,5-dibromo- (A3) and 3-tert-butyl- (A4) substituted derivatives. The tetradentate ligands were then reacted with copper-, manganese- and zinc-acetate producing the tetra-coordinate metal complexes which were characterized by FTIR, UV-Visible spectroscopy, magnetic susceptibility and elemental analysis. Zinc complexes were characterized by 1H-NMR spectroscopy. Density functional theory (DFT) calculations at the B3LYP/6-31G(d) level of theory were carried out to fully optimize and examine the molecular geometries of complexes. Subsequently, IR vibrational and UV-Vis absorption spectra were computed and correlated with the observed values and the results are in good agreement with the experimental data. The anticancerous and antiproliferative activity of the A3 ligand and its metal complexes were determined.

Słowa kluczowe

EN

tetradentate schiff base; symmetrical metal complexes; DFT calculation; spectroscopy; anticancerous; antiproliferative

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2021
• Tom: Vol. 23, nr 1
• Strony: 7--15
• Opis fizyczny: Bibliogr. 38 poz., rys., tab., wz.

Twórcy

autor

Ababneh Taher S.

• Department of Chemistry Yarmouk University Irbid, Jordan

autor

El-Khateeb Mohammad

• Chemistry Department Jordan University of Science and Technology Irbid, Jordan

autor

Tanash Aissar K.

• Department of Chemistry Yarmouk University Irbid, Jordan

autor

AL-Shboul Tareq M.A.

• Department of Chemistry and Chemical Technology Tafila Technical University Tafila, Jordan

autor

Shammout Mohammad Jamal A.

• Department of Basic and Applied Sciences Zarqa University College, Al-Balqa Applied University Al-Salt, Jordan

autor

Jazzazi Taghreed M.A.

• Department of Chemistry Yarmouk University Irbid, Jordan

autor

Alomari Mohammad

• Department of Chemistry and Chemical Technology Tafila Technical University Tafila, Jordan

autor

Daoud Safa

• Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy Applied Science Private University Amman, Jordan

autor

Talib Wamidh H.

• Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy Applied Science Private University Amman, Jordan

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).